drugset / Trial / NCT01752959
A Comparison of Esmolol and Remifentanil to Reduce Blood Loss
RandomizedParallel-groupOpen-label
Summary
In this prospective randomized study we aimed to compare the effects of esmolol and remifentanil on intraoperative bleeding surgical field conditions in nasal surgery
Timeline
- Start
- 2012-07
- Primary completion
- 2012-12
- Completion
- 2012-12
Publications
- Background Degoute CS, Ray MJ, Manchon M, Dubreuil C, Banssillon V. Remifentanil and controlled hypotension; comparison with nitroprusside or esmolol during tympanoplasty. Can J Anaesth. 2001 Jan;48(1):20-7. doi: 10.1007/BF03019809.
- Background Shen PH, Weitzel EK, Lai JT, Wormald PJ, Ho CS. Intravenous esmolol infusion improves surgical fields during sevoflurane-anesthetized endoscopic sinus surgery: a double-blind, randomized, placebo-controlled trial. Am J Rhinol Allergy. 2011 Nov-Dec;25(6):e208-11. doi: 10.2500/ajra.2011.25.3701.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Esmolol | Other / unclassified | 50 ug/kg | Intravenous |
| Subject | Esmolol | Other / unclassified | 500 ug/kg | Intravenous |
| Comparator | Remifentanil | Small molecule | 0.1 ug/kg | Intravenous |
| Comparator | Remifentanil | Small molecule | 0.3 ug/kg | Intravenous |