drugset / Trial / NCT01756989
ANGIOCOMB Antiangiogenic Therapy for Pediatric Patients With Diffuse Brain Stem and Thalamic Tumors
Phase 2
Completed
50 enrolled
Helsinki University Central Hospital
Kuopio University Hospital · collabOulu University Hospital · collabTampere University Hospital · collabTurku University Hospital · collab
NaSingle-groupOpen-labelTreatment
Summary
The purpose of this study is to determine whether initial local irradiation with topotecan and following oral antiangiogenic drugs, thalidomide, celecoxib and etoposide are effective in the treatment of pediatric diffuse brainstem tumor.
Timeline
- Start
- 2005-01
- Primary completion
- 2013-12
- Completion
- 2013-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Celecoxib | Other / unclassified | 7 mg/kg | Oral |
| Subject | Celecoxib | Other / unclassified | 230 mg/m2 | Oral |
| Subject | Etoposide | Small molecule | 70 mg/m2 | Oral |
| Subject | Thalidomide | Other / unclassified | 6 mg/kg | Oral |