drugset / Trial / NCT01759875
Effects of Gastric pH on the Pharmacokinetics of Atazanavir
RandomizedCrossoverOpen-labelBasic science
Summary
The goal of this study is to evaluate the ability of a natural supplement (betaine hydrochloride) to affect the absorption of atazanavir in healthy volunteers. The investigators predict that betaine hydrochloride will increase the absorption of atazanavir in volunteers pre-treated with proton-pump inhibitors (PPIs).
Timeline
- Start
- 2013-01
- Primary completion
- 2014-01
- Completion
- 2014-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Atazanavir | Other / unclassified | 300 mg | Oral |
| Subject | Betaine | Small molecule | 1500 mg | Oral |
| Subject | Rabeprazole | Small molecule | 20 mg | Oral |
| Comparator | Ritonavir | Other / unclassified | 100 mg | Oral |
Indications
No indication recorded.