Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy

Summary

Extensive clinical studies have shown that intraoperative infusion high dose of remifentanil (0.2ug/kg/min) induced postoperative hyperalgesia. Recent experimental study however suggests that higher dose of remifentanil may attenuate postoperative hyperalgesia. Thus, the present study is designed as a "proof of principle" study and hypothesizes that higher dose of remifentanil may reduce postoperative pain in patients.

Timeline

Start

2012-12

Primary completion

2013-03

Completion

—

Outcome

Met primary endpoint

paper Postoperative morphine consumption was much lower in the HD group compared with the RD group (1.27 ± 1.88 mg vs. 0.35 ± 1.25 mg, p = 0.033). PMID 24667391 ↗

paper VAS scores were lower 30 min postoperatively in the HD group PMID 24667391 ↗

paper (t = 3.427, p = 0.0043, RD group vs. HD group). PMID 24667391 ↗

Publications

• Zhang YL, Ou P, Lu XH, Chen YP, Xu JM, Dai RP. Effect of intraoperative high-dose remifentanil on postoperative pain: a prospective, double blind, randomized clinical trial. PLoS One. 2014 Mar 25;9(3):e91454. doi: 10.1371/journal.pone.0091454. eCollection 2014.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Remifentanil	Small molecule	0.2 ug/kg	—
Subject	Remifentanil	Small molecule	1.2 ug/kg	—

Indications