Sildenafil for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury.

Phase 2 Completed 59 enrolled Uniformed Services University of the Health Sciences Center for Neuroscience and Regenerative Medicine (CNRM) · collab National Institute of Neurological Disorders and Stroke (NINDS) · collab National Institutes of Health (NIH) · collab

RandomizedCrossoverQuadruple-blindTreatment

Summary

The purpose of this study is to determine whether sildenafil (Viagra®) is effective in improving cerebral blood flow and cerebrovascular reactivity inpatients who have persistent symptoms at least 6 months after a traumatic brain injury (TBI).

Timeline

Start: 2013-01
Primary completion: 2015-12
Completion: 2015-12

Publications

Reddy P, Izzetoglu M, Shewokis PA, Sangobowale M, Diaz-Arrastia R, Izzetoglu K. Evaluation of fNIRS signal components elicited by cognitive and hypercapnic stimuli. Sci Rep. 2021 Dec 6;11(1):23457. doi: 10.1038/s41598-021-02076-7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sildenafil	Unknown	25 mg	Oral
Subject	Sildenafil	Unknown	50 mg	Oral

Sildenafil for Cerebrovascular Dysfunction in Chronic Traumatic Brain Injury.

Summary

Timeline

Publications

Drugs

Indications