Glucocorticoid Induced Whole Body Catabolisme

Phase 2 Completed 19 enrolled University of Aarhus The Ministry of Science, Technology and Innovation, Denmark · collab

RandomizedCrossoverQuadruple-blindBasic science

Summary

The main purpose of the trial is to advance our knowledge on the possible mechanism underlying the catabolic effects of long-term treatment with glucocorticoid.

Timeline

Start: 2013-01
Primary completion: 2014-06
Completion: 2014-06

Publications

Ramshanker N, Jessen N, Voss TS, Pedersen SB, Jorgensen JOL, Nielsen TS, Frystyk J, Moller N. Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans. Metabolism. 2019 Oct;99:1-10. doi: 10.1016/j.metabol.2019.06.013. Epub 2019 Jun 29.
Ramshanker N, Aagaard M, Hjortebjerg R, Voss TS, Moller N, Jorgensen JOL, Jessen N, Bjerring P, Magnusson NE, Bjerre M, Oxvig C, Frystyk J. Effects of Prednisolone on Serum and Tissue Fluid IGF-I Receptor Activation and Post-Receptor Signaling in Humans. J Clin Endocrinol Metab. 2017 Nov 1;102(11):4031-4040. doi: 10.1210/jc.2017-00696.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Prednisolone	Other / unclassified	37.5 mg	—

Indications

No indication recorded.