drugset / Trial / NCT01762891
CI(R)CA : Coumadin Interaction With Rofecoxib, Celecoxib and Acetaminophen
NaSingle-groupTriple-blindTreatment
Summary
Coumadin drug-drug interactions (DDI) are frequent. Patients in permanent use of coumadin are advised to avoid traditional nonsteroidal antiinflammatory drugs to avoid risk of bleeding. New selctive cyclooxygesase 2 inhibitors arisen as potential option for treating pain and inflamation in these patients once interactions with coumadin are supposed to be lower. The CI(R)CA study was made to evaluate in a prospective fashion the occurrence of DDI with new cyclooxygenase antiinflammatory drugs and coumadin when compared to acetaminophen and placebo.
Timeline
- Start
- 2003-03
- Primary completion
- 2006-07
- Completion
- 2009-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Acetaminophen | Small molecule | 3 g | Oral |
| Subject | Celecoxib | Other / unclassified | 200 mg | Oral |
| Subject | rofecoxib | Small molecule | 25 mg | Oral |