drugset / Trial / NCT01772797

Phase Ib Study of LDK378 and AUY922 in ALK-rearranged Non-small Cell Lung Cancer

NCT01772797

Phase 1 Completed 22 enrolled Novartis Pharmaceuticals
NaSingle-groupOpen-labelTreatment

Summary

The primary purpose of the study is to estimate the maximum tolerated dose of the combination of LDK378 and AUY922. This study will assess the safety, tolerability, pharmacokinetics and preliminary evidence of anti-tumor activity of the combination of LDK378 and AUY922 in ALK-rearranged non-small cell lung cancer.

Timeline

Start
2013-06
Primary completion
2016-01
Completion
2016-01

Drugs

EvaluationDrugModalityDoseRoute
Subject AUY922 Small molecule Intravenous
Subject Ceritinib Small molecule Oral