Effects of Cerebral Hypoperfusion and Its Reversal on Late-Life Depression

Summary

This pilot proposal will test the hypothesis that altered cerebral vessel reactivity and cerebral hypoperfusion (decreased blood flow to the brain) is a core mechanism underlying the relationship between vascular disease and depression in older adults. The long-term objective of this line of research is to: A) determine the relationship between vascular reactivity, cerebral hypoperfusion and the persistence of late-life depression and B) determine if improving cerebral perfusion with angiotensin receptor blockers (ARBs) improves depression outcomes.

Timeline

Start

2013-05

Primary completion

2015-03

Completion

2015-03

Drugs

Indications