Mechanisms of Sleep Disruption Hyperalgesia

Completed 100 enrolled Johns Hopkins University National Institute on Drug Abuse (NIDA) · collab

RandomizedCrossoverDouble-blindBasic science

Summary

Twenty percent of Americans suffer from chronic pain. Sleep disturbance is similarly prevalent and among the most common and disabling neurobehavioral problems associated with chronic pain. This research is designed to evaluate the effects of disrupted sleep patterns on mood, inflammation, the perception of pain, and pain relief. This study will help researchers understand the relationship between sleep and pain, and how sleep disturbance might influence chronic pain conditions.

Timeline

Start: 2013-05
Primary completion: 2018-01
Completion: 2019-03-12

Outcome

Met primary endpoint

paper and decreases in hPTH ( P = 0.02). PMID 36314570 ↗

Publications

Irwin MR, Olmstead R, Bjurstrom MF, Finan PH, Smith MT. Sleep disruption and activation of cellular inflammation mediate heightened pain sensitivity: a randomized clinical trial. Pain. 2023 May 1;164(5):1128-1137. doi: 10.1097/j.pain.0000000000002811. Epub 2022 Oct 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Morphine	Other / unclassified	0.08 mg/kg	Intravenous

Indications

No indication recorded.