drugset / Trial / NCT01805037
Brentuximab Vedotin + Rituximab as Frontline Therapy for Pts w/ CD30+ and/or EBV+ Lymphomas
NaSingle-groupOpen-labelTreatment
Summary
The purpose of this study is to evaluate how safe and effective the combination of two different drugs (brentuximab vedotin and rituximab) is in patients with certain types of lymphoma. This study is for patients who have a type of lymphoma that expresses a tumor marker called CD30 and/or a type that is associated with the Epstein-Barr virus (EBV-related lymphoma) and who have not yet received any treatment for their cancer, except for dose-reduction or discontinuation (stoppage) of medications used to prevent rejection of transplanted organs (for those patients who have undergone transplantation). This study is investigating the combination of brentuximab vedotin and rituximab as a first treatment for lymphoma patients
Timeline
- Start
- 2013-03-05
- Primary completion
- 2017-09-18
- Completion
- 2018-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Brentuximab Vedotin | Monoclonal antibody | — | Intravenous |
| Subject | Rituximab | Monoclonal antibody | — | Intravenous |
Indications
Burkitt lymphoma
Epstein-Barr virus infection
Hodgkins lymphoma
MALT lymphoma
T-cell large granular lymphocyte leukemia
Waldenstrom macroglobulinemia
adult T-cell leukemia/lymphoma
anaplastic large cell lymphoma
angioimmunoblastic T-cell lymphoma
chronic lymphocytic leukemia/small lymphocytic lymphoma
extranodal nasal NK/T cell lymphoma
grade III lymphomatoid granulomatosis
hepatosplenic T-cell lymphoma
intraocular lymphoma
large-cell immunoblastic lymphoma
mantle cell lymphoma
mycosis fungoides
nodal marginal zone B-cell lymphoma
peripheral T-cell lymphoma, not otherwise specified
post-transplant lymphoproliferative disease
primary cutaneous B-cell lymphoma
refractory hairy cell leukemia
small intestine lymphoma
splenic marginal zone lymphoma
testicular lymphoma