Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence

Summary

The proposed protocol is a multi-site double-blind, placebo-controlled outpatient study of the safety and efficacy of Adderall-XR (MAS-ER) and topiramate in the treatment of cocaine dependence. 198 patients will be enrolled and 176 patients randomized in a 14-week trial. The proportion of participants achieving sustained cocaine abstinence for three consecutive weeks at the end of the study will be significantly greater for the combined pharmacotherapies group compared to the placebo group.

Timeline

Start

2013-07

Primary completion

2017-06

Completion

2017-06

Drugs

Indications