Effect of Metformin on Vascular and Mitochondrial Function in Type 1 Diabetes

Summary

Insulin resistance (IR) is an important contributor to increased cardiovascular disease risk in type 1 diabetes (T1D). The purpose of this study is to measure the effect of metformin on insulin sensitivity, vascular function and compliance, and mitochondrial function in T1D. The long term goal is to identify novel non-glycemic approaches to managing cardiovascular disease risk in T1D. The results of this study may validate a novel approach to T1D treatment that could significantly improve current management of cardiovascular disease risk in this high risk population.

Timeline

Start

2011-06

Primary completion

2017-03-24

Completion

2017-03-24

Drugs

Indications