drugset / Trial / NCT01822665
Gastrointestinal Safety Evaluation of Two Over the Counter Analgesics
RandomizedCrossoverSingle-blindTreatment
Summary
This study evaluated the effect of oral fast-dissolving formulations of paracetamol and ibuprofen on the lining of the stomach and duodenum (gastrointestinal mucosa). Endoscopic examinations were conducted to determine the gastrointestinal damage produced post a 7 day treatment regimen.
Timeline
- Start
- 2012-02
- Primary completion
- 2012-07
- Completion
- 2012-07
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetaminophen | Small molecule | 500 mg | Oral |
| Comparator | Ibuprofen | Small molecule | 400 mg | Oral |