Investigating the Efficacy of a Dentifrice in Providing Long Term Relief From Dentinal Hypersensitivity

Summary

Clinical studies have demonstrated long term relief from dentine hypersensitivity with twice daily brushing of a toothpaste containing stannous fluoride in comparison to marketed (negative) controls. The aim of this study is to evaluate the effectiveness of a stannous fluoride dentifrice in the treatment of dentinal hypersensitivity compared to a marketed (negative) control, over a period of 56 days (8 weeks) with twice daily brushing.

Timeline

Start

2013-02

Primary completion

2013-05

Completion

2013-05

Outcome

Met primary endpoint

registry p <0.0001; Adjusted Mean -1.29 (95% CI -1.53 to -1.06); ANCOVA NCT01827670 ↗

paper At 4 and 8 weeks, between treatment analyses found the test dentifrice to be significantly better than the negative control dentifrice in relieving dentin hypersensitivity PMID 26437498 ↗

Publications

• Parkinson CR, Jeffery P, Milleman JL, Milleman KR, Mason S. Confirmation of efficacy in providing relief from the pain of dentin hypersensitivity of an anhydrous dentifrice containing 0.454% with or without stannous fluoride in an 8-week randomized clinical trial. Am J Dent. 2015 Aug;28(4):190-6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	sodium monofluorophosphate	Unknown	0.76 %	Topical
Subject	stannous fluoride	Small molecule	0.454 %	Topical

Indications