stannous fluoride
Trials 54
| Phase | Registry id | Dates | Indication | Sponsor | Status | Outcome |
|---|---|---|---|---|---|---|
| Phase 21 trial | ||||||
| Phase 2 | NCT03361774 | Oct → Dec 2018 | dentin sensitivity | GlaxoSmithKline | Withdrawn | No outcome recorded |
| Phase 2/31 trial | ||||||
| Phase 2/3 | NCT07223060 | May → Oct 2017 | dental pulp calcification | Colgate Palmolive | Completed | No outcome recorded |
| Phase 318 trials · 5 met primary · 2 missed | ||||||
| Phase 3 | NCT07803484 | Sep 2026 → Mar 2028 expected | gingivitis | Colgate Palmolive | Not yet recruiting | No outcome recorded |
| Phase 3 | NCT07458464 | May → Jun 2026 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT07398846 | Jan → Apr 2026 | — | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT07210138 | Aug → Dec 2025 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT06427499 | Apr → Aug 2024 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT06300905 | Jun → Jul 2023 | mouth disorder | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT06353165 | Mar → Apr 2023 | — | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT06300866 | Aug 2020 → Mar 2021 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT03546491 | May → Jun 2018 | — | Procter and Gamble | Completed | No outcome recorded |
| Phase 3 | NCT07223073 | Dec 2017 → Jan 2018 | mouth disorder | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT03852056 | May → Dec 2017 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT02832375 | Mar → May 2016 | dentin sensitivity | GlaxoSmithKline | Completed | Met primary |
| Phase 3 | NCT04123665 | May → Dec 2013 | gingivitis | GlaxoSmithKline | Completed | Met primary |
| Phase 3 | NCT01827670 | Feb → May 2013 | dentin sensitivity | GlaxoSmithKline | Completed | Met primary |
| Phase 3 | NCT01592851 | Apr → May 2012 | dentin sensitivity | GlaxoSmithKline | Completed | Met primary |
| Phase 3 | NCT03072719 | Mar → Jun 2012 | dentin sensitivity | GlaxoSmithKline | Completed | Missed primary |
| Phase 3 | NCT01592864 | Mar → May 2012 | dentin sensitivity | GlaxoSmithKline | Completed | Met primary |
| Phase 3 | NCT00762177 | May → Sep 2008 | — | Colgate Palmolive | Completed | Missed primary |
| Phase 410 trials · 1 met primary | ||||||
| Phase 4 | NCT07807397 | Sep 2026 → Sep 2027 expected | dental caries, gingivitis | Colgate Palmolive | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07619729 | May 2026 → Jan 2028 expected | dental caries, periodontal disorder, type 2 diabetes mellitus | Colgate Palmolive | Enrolling by invitation | No outcome recorded |
| Phase 4 | NCT04763044 | Mar → Jul 2021 | dental caries | Procter and Gamble | Completed | No outcome recorded |
| Phase 4 | NCT04050722 | Oct → Nov 2019 | gingivitis | GlaxoSmithKline | Completed | Met primary |
| Phase 4 | NCT05731778 | Dec 2018 → Dec 2020 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| Phase 4 | NCT03936569 | Oct 2018 → Jan 2019 | gingivitis | Procter and Gamble | Completed | No outcome recorded |
| Phase 4 | NCT03936556 | Feb → Jun 2018 | gingivitis | Procter and Gamble | Completed | No outcome recorded |
| Phase 4 | NCT07211061 | Sep → Nov 2011 | gingivitis | Procter and Gamble | Completed | No outcome recorded |
| Phase 4 | NCT01317446 | Nov 2010 → Jan 2012 | gingivitis | Technical University Dresden | Completed | No outcome recorded |
| Phase 4 | NCT01128946 | Nov 2009 → Mar 2010 | dental caries | GlaxoSmithKline | Completed | No outcome recorded |
| Phase not applicable24 trials · 4 met primary · 3 missed | ||||||
| — | NCT07704905 | Jul → Sep 2026 | gingivitis | HALEON | Completed | No outcome recorded |
| — | NCT07352956 | Jan → Apr 2026 | dentin sensitivity | HALEON | Completed | No outcome recorded |
| — | NCT07169188 | Sep → Dec 2025 | gingivitis | HALEON | Completed | No outcome recorded |
| — | NCT06949072 | Apr → Sep 2025 | dental caries | HALEON | Completed | No outcome recorded |
| — | NCT07640399 | Mar → Jun 2025 | gingivitis | Church & Dwight Company, Inc. | Completed | No outcome recorded |
| — | NCT06733285 | Feb → May 2025 | dentin sensitivity | HALEON | Completed | No outcome recorded |
| — | NCT07419737 | Oct → Dec 2024 | smooth surface dental caries | Church & Dwight Company, Inc. | Completed | No outcome recorded |
| — | NCT06602466 | Sep → Dec 2024 | gingivitis | HALEON | Completed | Missed primary |
| — | NCT07425509 | Sep → Nov 2024 | — | Church & Dwight Company, Inc. | Completed | No outcome recorded |
| — | NCT07419672 | Aug → Nov 2024 | dental caries | Church & Dwight Company, Inc. | Completed | No outcome recorded |
| — | NCT06354270 | Apr → Jun 2024 | dentin sensitivity | HALEON | Completed | Met primary |
| — | NCT06143670 | Nov 2023 → Mar 2024 | gingivitis | HALEON | Completed | Met primary |
| — | NCT05750745 | May → Sep 2023 | dentin sensitivity | HALEON | Completed | Missed primary |
| — | NCT06659471 | Mar → Jun 2022 | gingival disorder | Procter and Gamble | Completed | No outcome recorded |
| — | NCT05916508 | Oct → Nov 2020 | gingivitis | Procter and Gamble | Completed | Met primary |
| — | NCT03296657 | Aug → Sep 2017 | — | Procter and Gamble | Completed | No outcome recorded |
| — | NCT02752958 | May 2016 → Feb 2017 | dentin sensitivity | GlaxoSmithKline | Completed | Mixed |
| — | NCT02750943 | Nov 2015 → Mar 2016 | gingivitis | GlaxoSmithKline | Completed | Met primary |
| — | NCT02613130 | Nov → Dec 2015 | mouth disorder | Procter and Gamble | Completed | No outcome recorded |
| — | NCT02574221 | Aug → Oct 2015 | gingivitis | Procter and Gamble | Completed | No outcome recorded |
| — | NCT02543060 | Jun → Aug 2015 | gingivitis | Procter and Gamble | Completed | No outcome recorded |
| — | NCT02221349 | Aug → Oct 2014 | dentin sensitivity | Procter and Gamble | Completed | No outcome recorded |
| — | NCT01549587 | Feb 2012 → Feb 2014 | gingivitis, pregnancy disorder | Procter and Gamble | Completed | No outcome recorded |
| — | NCT01494649 | Sep 2011 | dentin sensitivity, hypersensitivity reaction disease | GlaxoSmithKline | Completed | Missed primary |
| Comparator or background therapy21 trials | ||||||
| Phase 1 | NCT06962956 Comparator | Apr → Oct 2025 overdue | gingivitis | Procter and Gamble | Active not recruiting | No outcome recorded |
| Phase 2 | NCT06892834 Comparator | Mar → Jun 2025 | gingivitis | Procter and Gamble | Completed | No outcome recorded |
| Phase 3 | NCT07215767 Comparator | Sep 2025 → Aug 2026 overdue | dentin sensitivity | HALEON | Active not recruiting | No outcome recorded |
| Phase 3 | NCT06244290 Comparator | Sep → Oct 2020 | dentin sensitivity | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT06242769 Comparator | Jul → Sep 2020 | — | Colgate Palmolive | Completed | No outcome recorded |
| Phase 3 | NCT03296072 Comparator | Nov 2017 → Jan 2018 | tooth erosion, non-bacterial | GlaxoSmithKline | Completed | Met primary |
| Phase 3 | NCT02193165 Comparator | Jul → Aug 2014 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| Phase 4 | NCT06966492 Comparator | Sep 2026 → Jun 2027 expected | gingivitis | Colgate Palmolive | Not yet recruiting | No outcome recorded |
| Phase 4 | NCT07158112 Comparator | Aug → Dec 2025 overdue | gingivitis | Procter and Gamble | Active not recruiting | No outcome recorded |
| Phase 4 | NCT04033575 Comparator | Mar → Jun 2019 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| Phase 4 | NCT02360995 Comparator | Jun → Aug 2014 | gingivitis | Colgate Palmolive | Completed | No outcome recorded |
| — | NCT06660069 Comparator | Nov 2024 → Mar 2025 | gingivitis, smooth surface dental caries | HALEON | Completed | Met primary |
| — | NCT06140758 Comparator | Jul → Dec 2023 | dental caries | Procter and Gamble | Completed | No outcome recorded |
| — | NCT05326373 Comparator | Apr → Jun 2022 | gingivitis | Procter and Gamble | Completed | No outcome recorded |
| — | NCT05916521 Comparator | Nov 2021 → Feb 2022 | gingivitis | Procter and Gamble | Completed | No outcome recorded |
| — | NCT06140771 Comparator | Oct 2021 → Feb 2022 | gingivitis | Procter and Gamble | Completed | No outcome recorded |
| — | NCT04977778 Comparator | Sep 2021 → Jul 2023 | gingivitis | University of L'Aquila | Completed | No outcome recorded |
| — | NCT03965039 Comparator | Jul → Oct 2019 | dentin sensitivity | Procter and Gamble | Completed | No outcome recorded |
| — | NCT02841839 Background | Jun 2016 | — | Procter and Gamble | Completed | No outcome recorded |
| — | NCT02613117 Background | Nov 2015 → Jun 2016 | dentin sensitivity | Procter and Gamble | Completed | No outcome recorded |
| — | NCT02513212 Background | Jul → Sep 2015 | dentin sensitivity | Procter and Gamble | Completed | No outcome recorded |
Evidence & citations 10 cited values
Every value below carries the sentence it was read from. 81 sources stand behind the page.
| Field | Value | Cited text |
|---|---|---|
| Known as | stannous fluoride | “The purpose of this study is to investigate and characterize the Dentine Hypersensitivity (DH) protection profiles of a 0.454 percent (%) Stannous Fluoride (SnF2) toothpaste...” NCT06733285 ↗72“The aim of this study is to evaluate the ability of an experimental toothpaste, containing 0.454 percent (%) Stannous Fluoride (SnF2) to improve gingival health and reduce...” NCT07169188 ↗ “An 8-Week Randomized, Controlled, Examiner-Blind, Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Stannous Fluoride in Improving Gingival Health” NCT07704905 ↗ “0.454% Stannous Fluoride, 0.3% Zinc Chloride,1% Alumina toothpaste containing 1100 parts per million (ppm) fluoride.” NCT06602466 ↗ “Participants use a 0.12% chlorhexidine mouthwash and stannous fluoride toothpaste for 3 weeks (Regimen I).” NCT07803484 ↗ “two toothpastes containing stannous fluoride (SnHW and CPH) as compared to Regular Fluoride Toothpaste” NCT04033575 ↗ “dentifrice containing stannous fluoride (Colgate-Palmolive Company, New York, NY, USA)” NCT06244290 ↗ “0.45% Stannous Fluoride Toothpaste, CPC-Zinc Fluoride Mouthwash, Gummy Toothbrush” NCT07210138 ↗ “0.454 percentage (%) weight/weight (w/w) stannous fluoride (SnF2) toothpastes” NCT05750745 ↗ “0.454 percent (%) weight/weight (w/w) stannous fluoride (SnF2) toothpaste” NCT07352956 ↗ “toothpaste containing the chemotherapeutic agent stannous fluoride” PMID 34511098 ↗ Sep 2021 |
| Known as | amine fluoride/stannous fluoride | ClinicalTrials.gov intervention name — accepted as the source's own label NCT01317446 ↗ |
| Known as | Omnigel | ChEMBL registry synonym — accepted as the source's own label CHEMBL1909079 ↗ |
| Known as | Sensodyne Repair and Protect | “Participants will brush their teeth with Sensodyne Repair and Protect (containing 0.454% stannous fluoride)” NCT04050722 ↗ |
| Known as | SnF | “Stannous Fluoride Toothpaste (SnF)” NCT06242769 ↗4“Stannous Fluoride Toothpaste (SnF)” NCT07425509 ↗ “Stannous Fluoride Toothpaste (SnF)” NCT07419737 ↗ “Stannous Fluoride Toothpaste (SnF)” NCT06966492 ↗ |
| Known as | SnF2 | “The purpose of this study is to investigate and characterize the Dentine Hypersensitivity (DH) protection profiles of a 0.454 percent (%) Stannous Fluoride (SnF2) toothpaste...” NCT06733285 ↗11“The aim of this study is to evaluate the ability of an experimental toothpaste, containing 0.454 percent (%) Stannous Fluoride (SnF2) to improve gingival health and reduce...” NCT07169188 ↗ “marketed potassium nitrate (KNO3), marketed stannous fluoride (SnF2), experimental 1.5% oxalate, or negative control (NC) monofluorophosphate.” PMID 40444818 ↗ May 2025 “0.454 percent (%) Stannous Fluoride (SnF2), 0.3% Zinc Chloride (ZnCl2) and 1% Alumina” NCT06602466 ↗ “One effective occluding ingredient used in toothpastes is stannous fluoride (SnF2)” PMID 31164116 ↗ Jun 2019 “Stannous fluoride (SnF2) binds lipopolysaccharides to reduce plaque virulence.” PMID 39215289 ↗ Aug 2024 “0.454 percentage (%) weight/weight (w/w) stannous fluoride (SnF2) toothpastes” NCT05750745 ↗ “0.454 percent (%) weight/weight (w/w) stannous fluoride (SnF2) toothpaste” NCT07352956 ↗ “novel stannous fluoride (SnF2) and potassium nitrate (KNO3) dentifrice” NCT07215767 ↗ “0.454% stannous fluoride (SnF2) toothpaste in controlling gingivitis.” PMID 39118360 ↗ Aug 2024 “1100 ppm Stannous Fluoride (SnF2)” NCT04763044 ↗ |
| Known as | Tin fluoride (snf2) | ChEMBL registry synonym — accepted as the source's own label CHEMBL1909079 ↗ |
| Modality | Small molecule | — CHEMBL1909079 ↗ |
| Route | Oral | “10 ml qd, oral, topical, 6 months duration” NCT01317446 ↗ |
| Route | Topical | “10 ml qd, oral, topical, 6 months duration” NCT01317446 ↗ |