A Study to Evaluate the Efficacy of a Stannous Fluoride Toothpaste With a Cetylpyridinium Chloride Mouthwash in Improving Gingival Health and Reducing Plaque Accumulation
Summary
The aim of this study is to assess the ability of a marketed Cetylpyridinium Chloride (CPC) mouthwash alongside a marketed Stannous Fluoride (SnF2) toothpaste in improving gingival health and reducing plaque accumulation, compared to the use of a regular fluoride toothpaste alone in participants with clinically measurable plaque-induced gingivitis.
Timeline
- Start
- 2024-11-18
- Primary completion
- 2025-03-11
- Completion
- 2025-03-11
Outcome
Met primary endpoint
registry LEAST_SQUARES_MEAN Toothpaste/Mouthwash (SnF2 Toothpaste Followed by CPC Mouthwash): 10.1 (Standard Error 1.03) bleeding sites NCT06660069 ↗
registry LEAST_SQUARES_MEAN Negative Control Toothpaste (Sodium Fluoride Toothpaste): 24.1 (Standard Error 1.05) bleeding sites NCT06660069 ↗
registry analysis (superiority test); Toothpaste/Mouthwash (SnF2 Toothpaste Followed by CPC Mouthwash) vs Negative Control Toothpaste (Sodium Fluoride Toothpaste); p <0.0001 NCT06660069 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cetylpyridinium | Small molecule | 0.07 % | Oral |
| Comparator | sodium fluoride | Unknown | 0.243 % | Oral |
| Comparator | stannous fluoride | Small molecule | 0.454 % | Oral |