Investigating the Efficacy of an Occluding Dentifrice in Providing Relief From Dentinal Hypersensitivity

Summary

This single center, comparative design study will be used to investigate the efficacy of an experimental stannous fluoride containing dentifrice in relieving dentinal hypersensitivity (DH) after short term use compared with a standard fluoride dentifrice.

Timeline

Start

2016-03-01

Primary completion

2016-05-01

Completion

2016-05-12

Outcome

Met primary endpoint

registry p <0.0001; Least Square (LS) mean difference -0.45 (95% CI -0.577 to -0.319); ANCOVA NCT02832375 ↗

paper after 3d treatment, the Test toothpaste/brushing regimen significantly reduced DH compared to the Control regimen by both evaporative and tactile stimuli assessment PMID 31164116 ↗

Publications

• Creeth J, Gallob J, Sufi F, Qaqish J, Gomez-Pereira P, Budhawant C, Goyal C. Randomised clinical studies investigating immediate and short-term efficacy of an occluding toothpaste in providing dentine hypersensitivity relief. BMC Oral Health. 2019 Jun 4;19(1):98. doi: 10.1186/s12903-019-0781-x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	sodium monofluorophosphate	Unknown	0.76 %	—
Subject	stannous fluoride	Small molecule	0.454 %	Topical

Indications