drugset / Trial / NCT01839916
Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies
NaSingle-groupOpen-labelTreatment
Summary
This pilot phase II trial studies how well giving donor T cells after donor stem cell transplant works in treating patients with hematologic malignancies. In a donor stem cell transplant, the donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect.
Timeline
- Start
- 2013-04-04
- Primary completion
- 2018-08
- Completion
- 2018-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | therapeutic allogeneic lymphocytes | Cell therapy | — | Intravenous |
Indications
Burkitt lymphoma
Hodgkins lymphoma
MALT lymphoma
T-cell large granular lymphocyte leukemia
Waldenstrom macroglobulinemia
acute myeloid leukemia with 11q23 abnormalities
acute myeloid leukemia with t(8;21)(q22;q22) translocation
acute myeloid leukemia, del(5q31-q32)
acute myeloid leukemia, inv(16)(p13.1;q22)
acute myeloid leukemia, t(15;17)(q24;q21)
acute myeloid leukemia, t(16;16)(p13.1;q22)
adult T-cell leukemia/lymphoma
anaplastic large cell lymphoma
angioimmunoblastic T-cell lymphoma
blast phase chronic myelogenous leukemia, BCR-ABL1 positive
childhood acute lymphoblastic leukemia
childhood acute myeloid leukemia
childhood myelodysplastic syndrome
chronic lymphocytic leukemia/small lymphocytic lymphoma
extranodal nasal NK/T cell lymphoma
grade III lymphomatoid granulomatosis
hairy cell leukemia
hepatosplenic T-cell lymphoma
intraocular lymphoma
large-cell immunoblastic lymphoma
leukemia, myeloid, accelerated-phase
mantle cell lymphoma
mycosis fungoides and variants
nodal marginal zone B-cell lymphoma
peripheral T-cell lymphoma, not otherwise specified
post-transplant lymphoproliferative disease
primary cutaneous B-cell lymphoma
small intestine lymphoma
splenic marginal zone lymphoma
testicular lymphoma