Drugs / therapeutic allogeneic lymphocytes
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therapeutic allogeneic lymphocytes

Cell therapy

Developed for
leukemia · myelodysplastic syndrome · chronic lymphocytic leukemia/small lymphocytic lymphoma · Hodgkins lymphoma · plasma cell myeloma · plasma cell neoplasm · kidney cancer · Waldenstrom macroglobulinemia
+67 more · adult acute lymphoblastic leukemia · childhood acute myeloid leukemia · MALT lymphoma · mycosis fungoides and variants · nodal marginal zone B-cell lymphoma · splenic marginal zone lymphoma · acute myeloid leukemia with t(8;21)(q22;q22) translocation · acute myeloid leukemia, t(15;17)(q24;q21) · acute myeloid leukemia, t(16;16)(p13.1;q22) · adult T-cell leukemia/lymphoma · breast cancer · Burkitt lymphoma · extranodal nasal NK/T cell lymphoma · grade III lymphomatoid granulomatosis · graft versus host disease · hairy cell leukemia · hepatosplenic T-cell lymphoma · intraocular lymphoma · large-cell immunoblastic lymphoma · leukemia, myeloid, accelerated-phase · lymphoma · mantle cell lymphoma · peripheral T-cell lymphoma, not otherwise specified · primary cutaneous B-cell lymphoma · acute myeloid leukemia · acute myeloid leukemia with 11q23 abnormalities · acute myeloid leukemia, del(5q31-q32) · acute myeloid leukemia, inv(16)(p13.1;q22) · anaplastic large cell lymphoma · angioimmunoblastic T-cell lymphoma · blast phase chronic myelogenous leukemia, BCR-ABL1 positive · cancer · childhood acute lymphoblastic leukemia · childhood myelodysplastic syndrome · chronic myeloid leukemia · cutaneous melanoma · myelodysplastic/myeloproliferative neoplasm · small intestine lymphoma · T-cell large granular lymphocyte leukemia · testicular lymphoma · acquired polycythemia vera · acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) · acute myeloid leukemia, FLT3 internal tandem duplication · acute myeloid leukemia, inv(3)(q21.3;q26.2) · acute myeloid leukemia, t(6;9)(p23;q34.1) · aplastic anemia · cervical cancer · childhood kidney cell carcinoma · chronic myelomonocytic leukemia · clear cell renal carcinoma · congenital amegakaryocytic thrombocytopenia · diffuse large B-cell lymphoma · follicular lymphoma · infectious disease · lymphoproliferative syndrome · melanoma · myelodysplastic/myeloproliferative disease · myelofibrosis · myeloproliferative neoplasm · papillary renal cell carcinoma · Philadelphia-positive myelogenous leukemia · post-transplant lymphoproliferative disease · primary cutaneous T-cell non-Hodgkin lymphoma · renal cell carcinoma · severe congenital neutropenia · therapy related acute myeloid leukemia and myelodysplastic syndrome · vaginal cancer
Investigated by
National Cancer Institute (NCI) · Fred Hutchinson Cancer Center · National Heart, Lung, and Blood Institute (NHLBI) · University of California, San Francisco · Rutgers, The State University of New Jersey · University of Chicago
+20 more · University of Maryland, Baltimore · University of Medicine and Dentistry of New Jersey · AIDS Malignancy Consortium · Alliance for Clinical Trials in Oncology · Case Comprehensive Cancer Center · Eastern Cooperative Oncology Group · Fox Chase Cancer Center · Jonsson Comprehensive Cancer Center · Masonic Cancer Center, University of Minnesota · Milton S. Hershey Medical Center · Robert Lowsky · Rutgers Cancer Institute of New Jersey · SWOG Cancer Research Network · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University · University of California, San Diego · University of Colorado, Denver · University of Edinburgh · University of Southern California · University of Texas Southwestern Medical Center · Yale University

Trials 42 · a red edge is where a trial was stopped

PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 18 trials
Phase 1 NCT01523223 Jan 2012 → Sep 2016 Burkitt lymphoma, Hodgkins lymphoma, MALT lymphoma, Waldenstrom macroglobulinemia +19 Robert Lowsky Completed No outcome recorded
Phase 1 NCT00769613 Aug 2008 → Aug 2014 cancer Milton S. Hershey Medical Center Unknown No outcome recorded
Phase 1 NCT00295971 Apr 2005 → Dec 2011 congenital amegakaryocytic thrombocytopenia, leukemia, myelodysplastic syndrome, severe congenital neutropenia University of California, San Francisco Completed No outcome recorded
Phase 1 NCT00104975 Feb 2005 → May 2008 leukemia, lymphoma, myelodysplastic syndrome, myelodysplastic/myeloproliferative neoplasm Yale University Completed No outcome recorded
Phase 1 NCT00176475 Jan 2005 → Feb 2008 leukemia, plasma cell neoplasm University of Medicine and Dentistry of New Jersey Terminated No outcome recorded
Phase 1 NCT00161187 May 2001 → Oct 2010 cancer University of Medicine and Dentistry of New Jersey Completed No outcome recorded
Phase 1 NCT00005946 Oct 2000 → Jun 2002 leukemia, myelodysplastic syndrome, plasma cell neoplasm University of Maryland, Baltimore Completed No outcome recorded
Phase 1 NCT00107354 Dec 1998 → Aug 2009 leukemia, myelodysplastic syndrome Fred Hutchinson Cancer Center Completed No outcome recorded
Phase 1/25 trials
Phase 1/2 NCT00248430 Aug 2003 → Jul 2007 graft versus host disease, leukemia, plasma cell neoplasm Fred Hutchinson Cancer Center Completed No outcome recorded
Phase 1/2 NCT00068718 May 2003 → Apr 2013 Hodgkins lymphoma, acute myeloid leukemia, adult acute lymphoblastic leukemia, blast phase chronic myelogenous leukemia, BCR-ABL1 positive +1 Fred Hutchinson Cancer Center Completed No outcome recorded
Phase 1/2 NCT00027547 Jul 2001 → Jul 2004 leukemia Fred Hutchinson Cancer Center Completed No outcome recorded
Phase 1/2 NCT00005851 Feb 2000 → Jul 2004 renal cell carcinoma Fred Hutchinson Cancer Center Completed No outcome recorded
Phase 1/2 NCT00003552 Jan 1999 → Oct 2002 melanoma National Heart, Lung, and Blood Institute (NHLBI) Terminated No outcome recorded
Phase 223 trials
Phase 2 NCT02587871 Dec 2018 → Nov 2020 childhood acute myeloid leukemia University of Southern California Withdrawn No outcome recorded
Phase 2 NCT01839916 Apr 2013 → Aug 2018 Burkitt lymphoma, Hodgkins lymphoma, MALT lymphoma, T-cell large granular lymphocyte leukemia +31 University of Chicago Completed No outcome recorded
Phase 2 NCT01760655 Dec 2012 → Apr 2022 Hodgkins lymphoma, acquired polycythemia vera, acute myeloid leukemia, FLT3 internal tandem duplication, acute myeloid leukemia, inv(3)(q21.3;q26.2) +11 Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University Completed No outcome recorded
Phase 2 NCT00853125 Feb 2009 → Feb 2014 kidney cancer Rutgers, The State University of New Jersey Terminated No outcome recorded
Phase 2 NCT00274846 Mar 2005 → Jun 2008 leukemia Masonic Cancer Center, University of Minnesota Completed No outcome recorded
Phase 2 NCT00176501 Aug 2004 → Aug 2008 kidney cancer Rutgers, The State University of New Jersey Terminated No outcome recorded
Phase 2 NCT00074269 Jul 2003 → Mar 2008 breast cancer University of California, San Diego Terminated No outcome recorded
Phase 2 NCT00096161 May 2003 → Feb 2015 Hodgkins lymphoma, Philadelphia-positive myelogenous leukemia, Waldenstrom macroglobulinemia, acute myeloid leukemia +4 Fred Hutchinson Cancer Center Completed No outcome recorded
Phase 2 NCT00053014 Apr 2003 → Jun 2005 leukemia SWOG Cancer Research Network Terminated No outcome recorded
Phase 2 NCT00027573 Oct 2001 → Jun 2006 kidney cancer Alliance for Clinical Trials in Oncology Completed No outcome recorded
Phase 31 trial
Phase 3 NCT00033475 Mar 2001 → ? lymphoproliferative syndrome University of Edinburgh Completed No outcome recorded
Phase not applicable4 trials
NCT00301860 Jan 2003 → Mar 2007 leukemia, lymphoma University of California, San Francisco Terminated No outcome recorded
NCT00005799 Nov 1999 → Jul 2002 Hodgkins lymphoma, MALT lymphoma, T-cell large granular lymphocyte leukemia, Waldenstrom macroglobulinemia +22 Fred Hutchinson Cancer Center Completed No outcome recorded
NCT00296023 Jan 1999 → Jun 2007 leukemia, myelodysplastic syndrome, myeloproliferative neoplasm, plasma cell neoplasm University of California, San Francisco Completed No outcome recorded
NCT00003196 Sep 1997 → Apr 2002 Burkitt lymphoma, MALT lymphoma, Waldenstrom macroglobulinemia, adult T-cell leukemia/lymphoma +19 Fred Hutchinson Cancer Center Completed No outcome recorded
Phase not stated1 trial
NCT00547235 Sep 2007 → Dec 2012 infectious disease, precancerous condition Fred Hutchinson Cancer Center No longer available No outcome recorded
Also used as a comparator or background therapy in 16 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 12 trials
Phase 1 NCT00080925 Background Feb 2004 → Dec 2010 leukemia, myelodysplastic syndrome, myelodysplastic/myeloproliferative neoplasm, plasma cell neoplasm National Institutes of Health Clinical Center (CC) Completed No outcome recorded
Phase 1 NCT00003243 Background Jan 1998 → ? leukemia, lymphoma, myelodysplastic syndrome, myelodysplastic/myeloproliferative disease Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Completed No outcome recorded
Phase 1/26 trials
Phase 1/2 NCT06866158 Background May → Aug 2024 overdue diabetic kidney disease PT. JES Kasih Nusantara Sejahterah Active not recruiting No outcome recorded
Phase 1/2 NCT00448357 Background Oct 2005 → Nov 2015 leukemia, myelodysplastic syndrome, myeloproliferative neoplasm, plasma cell neoplasm UNC Lineberger Comprehensive Cancer Center Completed No outcome recorded
Phase 1/2 NCT00245037 Background Jun 2005 → Aug 2015 leukemia, myelodysplastic syndrome, myelodysplastic/myeloproliferative neoplasm, plasma cell neoplasm +1 OHSU Knight Cancer Institute Completed No outcome recorded
Phase 1/2 NCT00281983 Background Jun 2000 → Jul 2010 B-cell chronic lymphocytic leukemia German CLL Study Group Completed No outcome recorded
Phase 1/2 NCT00005802 Background Jun 1999 → Mar 2005 leukemia Fred Hutchinson Cancer Center Completed No outcome recorded
Phase 28 trials
Phase 2 NCT01118013 Background Dec 2010 → Mar 2012 immunoproliferative disorder, leukemia, myelodysplastic syndrome, myelodysplastic/myeloproliferative neoplasm +1 Alliance for Clinical Trials in Oncology Terminated No outcome recorded
Phase 2 NCT00110058 Background Feb 2005 → Jul 2006 leukemia Fred Hutchinson Cancer Center Completed No outcome recorded
Phase 2 NCT00056095 Background Nov 2002 → Feb 2008 kidney cancer UNICANCER Completed No outcome recorded
Phase 2 NCT00043979 Background Sep 2002 → May 2009 sarcoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT00041288 Background Oct 2001 → Jan 2003 leukemia, lymphoma University of Texas Southwestern Medical Center Terminated No outcome recorded

Evidence & citations 8 cited values

Every value below carries the sentence it was read from. 59 sources stand behind the page.

FieldValueCited text
Known as therapeutic allogeneic lymphocytes ClinicalTrials.gov intervention name — accepted as the source's own label NCT00161187
53

NCT00004135

NCT00068718

NCT00104975

NCT00004878

NCT00080925

NCT00043979

NCT00296023

NCT00096161

NCT00074269

NCT00262886

NCT00003145

NCT00005851

NCT00547235

NCT00245037

NCT00274846

NCT01523223

NCT00003153

NCT00024128

NCT00003243

NCT00033475

NCT00853125

NCT00041288

NCT00301860

NCT00044954

NCT00066417

NCT00107354

NCT00002778

NCT00053014

NCT00003954

NCT00006261

NCT00005941

NCT01760655

NCT01118013

NCT00295971

NCT00027547

NCT00025519

NCT00027573

NCT00005946

NCT00006233

NCT00769613

NCT00006350

NCT00056095

NCT02587871

NCT00176501

NCT00005799

NCT00448357

NCT00003196

NCT00281983

NCT00176475

NCT00005801

NCT00005802

NCT01839916

NCT00248430

Known as allogeneic lymphocytes ClinicalTrials.gov intervention name — accepted as the source's own label NCT00110058
2

NCT00020176

NCT00003552

Known as allogeneic T lymphocytes Allogeneic T lymphocytes can induce regression of metastatic breast cancer through an immune-mediated graft-versus-tumor (GVT) effect” PMID 15314059 Aug 2004
Known as donor lymphocyte infusion “Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect.” NCT00296023
Known as Lymphocytes “DCL (Dendritic Cells+Lymphocytes) previously matured with S-Protein of SARS-CoV-2.” NCT06866158
Action Deplete “donor white blood cells that have been treated in the laboratory to kill cells infected with Epstein-Barr virus” NCT00033475
Modality Cell therapy “Donor lymphocyte infusions or second unmodified allogeneic bone marrow transplantation without GM-CSF is considered in case of primary or secondary engraftment failure.” NCT00002778
Route Intravenous “Patients receive initial cell dose of donor lymphocytes (CD3+ cells) IV over 15-30 minutes” NCT00003153