Oral Bicarbonate as Adjuvant for Pain Reduction in Patients With Tumor Related Pain

Phase 1 Terminated 9 enrolled H. Lee Moffitt Cancer Center and Research Institute Reliable Cancer Therapies · collab

NaSingle-groupOpen-labelSupportive care

Summary

The purpose of this study is to: * Determine how well people tolerate sodium bicarbonate taken by mouth in higher doses than those usually given for heartburn. * Determine if sodium bicarbonate can reduce cancer-related pain.

Timeline

Start: 2013-09
Primary completion: 2014-12
Completion: 2015-05

Outcome

Outcome not reported

Stopped: “Drugs unavailable. Study did not progress to Phase 2.”

Publications

Gillies RJ, Ibrahim-Hashim A, Ordway B, Gatenby RA. Back to basic: Trials and tribulations of alkalizing agents in cancer. Front Oncol. 2022 Nov 14;12:981718. doi: 10.3389/fonc.2022.981718. eCollection 2022.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	sodium bicarbonate	Diagnostic / imaging agent	9000 mg	Oral
Subject	sodium bicarbonate	Diagnostic / imaging agent	18000 mg	Oral
Subject	sodium bicarbonate	Diagnostic / imaging agent	27000 mg	Oral
Subject	sodium bicarbonate	Diagnostic / imaging agent	36000 mg	Oral