Metformin+Cytarabine for the Treatment of Relapsed/Refractory AML

Summary

The purpose of the study is to determine if metformin in combination with cytarabine is safe and effective. Participants in this research study have acute myeloid leukemia (AML) that has come back after initial treatment or has not gone away with initial therapy.There is evidence that metformin directly kills leukemia cells. Laboratory data have also shown that combinations of metformin with cytarabine are more efficient than each agent alone in killing leukemia cells in the laboratory.

Timeline

Start

2015-03-11

Primary completion

2016-01-21

Completion

2016-01-21

Outcome

Outcome not reported

Stopped (Enrollment): “Slow accrual”

Drugs

Indications