Interactions Between Intravenous Cocaine and Acetazolamide or Quinine

Summary

Background: \- Scientists are studying medications that may be useful in treating cocaine addiction. It is important in these studies to know whether study participants are always taking their medications as directed. This study will look at two chemicals to see if they can be used to determine whether participants are taking their medications as directed. Because acetazolamide and quinine can be measured in plasma and urine, they are good test subjects for this study. They will be given alone, and combined with intravenous cocaine. Objectives: \- To see how they body handles acetazolamide and quinine alone, and when combined with cocaine. Eligibility: \- Individuals between 18 and 50 years of age who have smoked or used IV cocaine for at least one year and at least three times per month during the three months prior to screening. Urine test positive for cocaine within the prior 6 months Design: * Participants will be screened with a physical exam and medical history. Blood and urine samples will also be collected. * This study will involve a 12-day inpatient stay at the National Institutes of Health. * On days 1, 5, and 10, participants will receive a dose of cocaine. Blood, urine, breath, and saliva samples will be collected up to 18 times a day for up to about 24 hours. * On days 2, 3, 4, and 5, participants will receive acetazolamide. Regular blood samples will be collected on Day 4. * Day 6 is a wash-out day with no drugs or blood tests. * On days 7, 8, 9, and 10, participants will receive quinine. Regular blood samples will be collected on Day 9. * On day 11, blood, urine, breath, and saliva samples will be collected in the early morning. Participants will be able to leave later in the day.

Timeline

Start

2012-10-24

Primary completion

2015-10-07

Completion

2015-10-07

Publications

• Background Alboliras ET, Porter CJ, Ritter DG, Danielson GK, Driscoll DJ. Progressive atrioventricular block during exercise in univentricular heart. Pacing Clin Electrophysiol. 1986 Nov;9(6):821-5. doi: 10.1111/j.1540-8159.1986.tb06631.x.
• Background Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005 Aug 4;353(5):487-97. doi: 10.1056/NEJMra050100. No abstract available.
• Background Dubbert PM, King A, Rapp SR, Brief D, Martin JE, Lake M. Riboflavin as a tracer of medication compliance. J Behav Med. 1985 Sep;8(3):287-99. doi: 10.1007/BF00870315.
• Bouhlal S, Ellefsen KN, Sheskier MB, Singley E, Pirard S, Gorelick DA, Huestis MA, Leggio L. Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses. Drug Alcohol Depend. 2017 Nov 1;180:68-75. doi: 10.1016/j.drugalcdep.2017.07.033. Epub 2017 Aug 31.

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Indications