Acetazolamide

also known as Diamox · Acz · Acetamox · Acetazolamida · Acetazolamide (Diamox 250 mg) · acetazolamide = Zoladin · ACETAZOLAMIDE SODIUM · Acetazolamide sodium salt · +21 more

Small molecule targets CA1, CA12, CA2, CA4 via inhibition

Developed for: obstructive sleep apnea syndrome · heart failure · acute mountain sickness · sleep apnea syndrome · pulmonary hypertension · central sleep apnea syndrome · disorder of acid-base balance · glaucoma
+49 more
· altitude sickness · cerebrospinal fluid leak · chronic obstructive pulmonary disease · congestive heart failure · intracranial vasospasm · obesity-hypoventilation syndrome · type 1 diabetes mellitus · Andersen-Tawil syndrome · autonomic nervous system disorder · brain glioma · cardiac rhythm disease · chronic mountain sickness · congenital disorder of glycosylation, type IAA · cystoid macular edema · drug induced central sleep apnea · Helicobacter pylori infectious disease · hepatocellular carcinoma · high altitude pulmonary edema · hypertensive disorder · intracranial hypertension · Landau-Kleffner syndrome · macular retinal edema · medulloadrenal hyperfunction · metastatic melanoma · multiple sclerosis · nephrotic syndrome · normal pressure hydrocephalus · obesity disorder · ocular hypertension · orthostatic hypotension · PMM2-congenital disorder of glycosylation · polycythemia due to hypoxia · respiratory failure · retinoschisis · small cell lung carcinoma · symptomatic heart failure · acute tubulointerstitial nephritis · central retinal artery occlusion · cisplatin toxicity · cysticercosis · epilepsy · inherited retinal dystrophy · myofascial pain syndrome · pseudotumor cerebri · schizoaffective disorder · schizophrenia · sleep disorder · spontaneous intracranial hypotension · thoracic aortic aneurysm
Investigated by: University of Zurich · University of California, San Diego · National Heart, Lung, and Blood Institute (NHLBI) · University of Miami · VA Office of Research and Development · Centre d'Expertise sur l'Altitude EXALT
+93 more
· Mayo Clinic · National Eye Institute (NEI) · National Institute on Drug Abuse (NIDA) · National Institutes of Health (NIH) · Rabin Medical Center · Stanford University · University Hospital, Antwerp · University of British Columbia · University of Sao Paulo · Ziekenhuis Oost-Limburg · Academic Medical Center - University of Amsterdam · American Heart Association · American Thoracic Society · Apnimed · Asan Medical Center · Azienda Ospedaliero-Universitaria di Parma · Azienda USL Reggio Emilia - IRCCS · Azienda USL di Parma · Bangor University · Breakthrough T1D · Brigham and Women's Hospital · Cairo University · Canadian Glaucoma Clinical Research Council · Centre Antoine Lacassagne · Centro Cardiologico Monzino · Children's Hospital of Philadelphia · Clinica Alemana de Santiago · Credit Valley EyeCare · Danish Headache Center · David Andrew Wellman · Fundação de Apoio ao Ensino Pesquisa e Assitência do HCFMRPUSP · Georgetown University · Göteborg University · Hasselt University · Hospital Son Llatzer · Hospital de Clinicas de Porto Alegre · Incannex Healthcare Ltd · Istituto Auxologico Italiano · Jessa Hospital · Ji Xunming,MD,PhD · John D. Dingell VA Medical Center · Juvenile Diabetes Research Foundation · Lucrecia Maria Burgos · M.D. Anderson Cancer Center · Masih Daneshvari Hospital · NYU Langone Health · National Center for Advancing Translational Sciences (NCATS) · National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov · National Center of Cardiology and Internal Medicine, Kyrgyz Republic · National Heart Institute, Egypt · National Institute of Neurological Disorders and Stroke (NINDS) · National University Hospital, Singapore · North Wales Research Committee, UK · Office of Rare Diseases (ORD) · Post Graduate Institute of Medical Education and Research, Chandigarh · Rare Diseases Clinical Research Network · Roche Diagnostics GmbH · STM Pharma PRO srl · Samara State Medical University · Satish R. Raj · Seattle Children's Hospital · Shahid Beheshti University of Medical Sciences · Shiraz University of Medical Sciences · Tehran University of Medical Sciences · The First Affiliated Hospital of Zhengzhou University · The University of Texas Health Science Center, Houston · US Department of Veterans Affairs · United States Army Research Institute of Environmental Medicine · Universitaire Ziekenhuizen KU Leuven · Universitas Diponegoro · University Hospitals Cleveland Medical Center · University of Alabama at Birmingham · University of Arizona · University of California, Los Angeles · all 99 on the full record

Regulatory milestones approvals, filings & regulatory actions · 1 recorded

Milestone	Jurisdiction	Brand	Indication	Date	Sentence it was read from
Approved	US (FDA)	DIAMOX	—	1953-07-27	fda.gov ↗

Trials 87 · started per year

today

US approved 1953

195219531954195519561957195819591960196119621963196419651966196719681969197019711972197319741975197619771978197919801981198219831984198519861987198819891990199119921993199419951996199719981999200020012002200320042005200620072008200920102011201220132014201520162017201820192020202120222023202420252026202720282029

Phase	Registry id	Dates	Indication	Sponsor	Status	Outcome
Phase 02 trials
Phase 0	NCT03806751	Feb 2025 → Feb 2027	—	University of Alabama at Birmingham	Withdrawn	No outcome recorded
Phase 0	NCT06110078	Jan → May 2024	obesity disorder	University of Arizona	Unknown	No outcome recorded
Phase 18 trials · 1 missed
Phase 1	NCT05470283	Sep 2022 → Apr 2027 expected	metastatic melanoma	M.D. Anderson Cancer Center	Active not recruiting	No outcome recorded
Phase 1	NCT03828474	Aug → Sep 2019	acute mountain sickness	Stanford University	Completed	Missed primary
Phase 1	NCT03467360	Aug 2019 → Oct 2026 expected	small cell lung carcinoma	Centre Antoine Lacassagne	Recruiting	No outcome recorded
Phase 1	NCT03011671	Oct 2018 → Dec 2026 expected	brain glioma	University of Chicago	Active not recruiting	No outcome recorded
Phase 1	NCT03424226	Aug → Sep 2018	acute mountain sickness	Stanford University	Completed	No outcome recorded
Phase 1	NCT01851473	Oct 2012 → Oct 2015	substance-related disorder	National Institute on Drug Abuse (NIDA)	Completed	No outcome recorded
Phase 1	NCT00839501	Dec 2008 → Jan 2011	Andersen-Tawil syndrome	University of Rochester	Terminated	No outcome recorded Stop: Enrollment
Phase 1	NCT00223691	Mar 2002 → Jan 2017	autonomic nervous system disorder, orthostatic hypotension	Vanderbilt University	Completed	Mixed
Phase 1/24 trials · 1 missed
Phase 1/2	NCT06091085	Jan 2024 → Dec 2027 expected	obstructive sleep apnea syndrome	Brigham and Women's Hospital	Recruiting	No outcome recorded
Phase 1/2	NCT05473364	Mar 2023 → Feb 2024	type 1 diabetes mellitus	University of California, San Diego	Completed	No outcome recorded
Phase 1/2	NCT05589753	May 2019 → Dec 2026 expected	sleep apnea syndrome	VA Office of Research and Development	Recruiting	No outcome recorded
Phase 1/2	NCT00262470	Apr 1997 → Dec 2029 expected	cardiac rhythm disease	Satish R. Raj	Active not recruiting	Missed primary
Phase 223 trials · 2 met primary
Phase 2	NCT07635563	Jul 2026 → Apr 2027 expected	obstructive sleep apnea syndrome	Incannex Healthcare Ltd	Recruiting	No outcome recorded
Phase 2	NCT06521476	Sep 2025 → Feb 2028 expected	drug induced central sleep apnea	University of Pittsburgh	Recruiting	No outcome recorded
Phase 2	NCT06981234	Aug 2024 → Dec 2026 expected	type 1 diabetes mellitus	University of California, San Diego	Recruiting	No outcome recorded
Phase 2	NCT05953610	Jan 2024 → Aug 2028 expected	obstructive sleep apnea syndrome	University of California, Los Angeles	Recruiting	No outcome recorded
Phase 2	NCT06043830	Oct 2023 → Dec 2025	central sleep apnea syndrome, chronic pain syndrome, obstructive sleep apnea syndrome, substance-related disorder	University of California, San Diego	Completed	No outcome recorded
Phase 2	NCT05804084	May 2023 → Oct 2026 expected	obstructive sleep apnea syndrome	University of California, San Diego	Recruiting	No outcome recorded
Phase 2	NCT06114537	Jan 2023 → Sep 2024	retinoschisis	Academic Medical Center - University of Amsterdam	Completed	No outcome recorded
Phase 2	NCT05616260	Dec 2022 → May 2025	obstructive sleep apnea syndrome	University of California, San Diego	Completed	No outcome recorded
Phase 2	NCT05448443	Jun 2022 → May 2024	obesity-hypoventilation syndrome	Istituto Auxologico Italiano	Completed	Met primary
Phase 2	NCT04639193	Dec 2020 → Jan 2022	obstructive sleep apnea syndrome	University of California, San Diego	Completed	Met primary
Phase 2	NCT04351061	May 2020 → Nov 2021	cerebrospinal fluid leak	University of Miami	Withdrawn	No outcome recorded
Phase 2	NCT03779594	Dec 2018 → Dec 2019	normal pressure hydrocephalus	Rabin Medical Center	Unknown	No outcome recorded
Phase 2	NCT02902133	Sep 2016 → Sep 2021	cerebrospinal fluid leak	University of Miami	Withdrawn	No outcome recorded
Phase 2	NCT02466074	Aug 2016 → Feb 2022	multiple sclerosis	The University of Texas Health Science Center, Houston	Terminated	No outcome recorded Stop: Enrollment
Phase 2	NCT02165644	Sep 2015	intracranial vasospasm, stroke disorder	University of Florida	Withdrawn	No outcome recorded
Phase 2	NCT02276989	Dec 2014 → Jan 2016	chronic pain syndrome	Georgetown University	Withdrawn	No outcome recorded Stop: Enrollment
Phase 2	NCT02090738	Mar → Dec 2014	Helicobacter pylori infectious disease	Yonsei University	Withdrawn	No outcome recorded
Phase 2	NCT02220803	Mar 2014 → Aug 2016	hypertensive disorder, obstructive sleep apnea syndrome	Göteborg University	Completed	No outcome recorded
Phase 2	NCT01867268	Oct 2012 → Apr 2015	isolated filum lipoma, lipomyelomeningocele, spinal dermal sinus, split cord malformation, composite type +1	Tehran University of Medical Sciences	Unknown	No outcome recorded
Phase 2	NCT01427192	Nov 2010 → Dec 2012	pulmonary hypertension, sleep apnea syndrome	University of Zurich	Completed	No outcome recorded
Phase 2	NCT00864838	Jun 2008 → Feb 2009	age-related macular degeneration, diabetic retinopathy	University of Sao Paulo	Completed	No outcome recorded
Phase 2	NCT00000115	Dec 1990 → Jun 1994	cystoid macular edema	National Eye Institute (NEI)	Completed	No outcome recorded
Phase 2	NCT00804921	—	diabetic retinopathy, macular retinal edema	University of Sao Paulo	Completed	No outcome recorded

Phase 2/35 trials · 2 missed
Phase 2/3	NCT07469722	Mar 2026 → Jan 2028 expected	congestive heart failure	Hospital de Clinicas de Porto Alegre	Not yet recruiting	No outcome recorded
Phase 2/3	NCT04679389	Mar 2021 → Jan 2024	PMM2-congenital disorder of glycosylation, congenital disorder of glycosylation, type IAA	Mayo Clinic	Terminated	Missed primary Stop: Business
Phase 2/3	NCT02755259	Jan 2017 → Apr 2019	pulmonary hypertension	University of Zurich	Completed	No outcome recorded
Phase 2/3	NCT02755298	Oct 2016 → Nov 2020	pulmonary hypertension	University of Zurich	Completed	Missed primary
Phase 2/3	NCT02904265	Sep 2016 → Jul 2019	Landau-Kleffner syndrome	Mayo Clinic	Terminated	No outcome recorded Stop: Enrollment
Phase 36 trials · 2 missed
Phase 3	NCT04915365	May 2021 → Dec 2022	altitude sickness, chronic obstructive pulmonary disease	University of Zurich	Unknown	No outcome recorded
Phase 3	NCT04611373	May → Dec 2020	hepatocellular carcinoma	The First Affiliated Hospital of Zhengzhou University	Unknown	No outcome recorded
Phase 3	NCT03720288	Oct 2018 → Oct 2019	heart failure	University of Sao Paulo General Hospital	Unknown	No outcome recorded
Phase 3	NCT02390284	Sep 2015 → Oct 2024	glaucoma	University of Miami	Terminated	No outcome recorded
Phase 3	NCT01499485	Nov 2011 → Feb 2015	chronic obstructive pulmonary disease, disorder of acid-base balance, obesity-hypoventilation syndrome	Hospital Son Llatzer	Completed	Missed primary
Phase 3	NCT00746954	Sep 2008 → Sep 2011	central sleep apnea syndrome, heart failure	VA Office of Research and Development	Terminated	Missed primary Stop: Enrollment
Phase 427 trials · 2 met primary · 2 missed
Phase 4	NCT07593612	Jun 2026 → Jan 2027 expected	heart failure	Lucrecia Maria Burgos	Not yet recruiting	No outcome recorded
Phase 4	NCT07118462	Jul 2024 → Dec 2025 overdue	acute mountain sickness	Centre d'Expertise sur l'Altitude EXALT	Recruiting	No outcome recorded
Phase 4	NCT06414759	Jul → Dec 2024 overdue	heart failure	Cairo University	Recruiting	No outcome recorded
Phase 4	NCT06475105	Apr → Nov 2024 overdue	heart failure	Universitas Diponegoro	Recruiting	No outcome recorded
Phase 4	NCT05802849	May 2023 → Aug 2025 overdue	congestive heart failure	Samara State Medical University	Recruiting	No outcome recorded
Phase 4	NCT05411991	Jun 2022 → Jul 2024	heart failure	Vrije Universiteit Brussel	Completed	Missed primary
Phase 4	NCT05300477	May 2022 → Sep 2023 overdue	polycythemia due to hypoxia	United States Army Research Institute of Environmental Medicine	Active not recruiting	No outcome recorded
Phase 4	NCT05023941	Dec 2021 → Aug 2022	acute mountain sickness	Ji Xunming,MD,PhD	Completed	Met primary
Phase 4	NCT04726982	Apr 2021 → Mar 2024	obstructive sleep apnea syndrome	University Hospital, Antwerp	Completed	No outcome recorded
Phase 4	NCT04062760	Dec 2019 → Dec 2021	heart failure	University of Parma	Unknown	No outcome recorded
Phase 4	NCT03377049	Jul 2019 → Jul 2022	acquired aneurysmal subarachnoid hemorrhage, intracranial vasospasm	University of Wisconsin, Madison	Completed	No outcome recorded
Phase 4	NCT03505788	Nov 2018 → Jan 2022	heart failure	Ziekenhuis Oost-Limburg	Completed	Met primary
Phase 4	NCT03490916	Mar → Apr 2018	high altitude pulmonary edema	Vincent Kan	Terminated	No outcome recorded
Phase 4	NCT02992938	Dec 2016 → Sep 2018	substance-related disorder	University of Chile	Completed	No outcome recorded
Phase 4	NCT02758470	Nov 2016 → Jun 2017	—	University of British Columbia	Completed	No outcome recorded
Phase 4	NCT02760121	May → Aug 2016	altitude sickness, pulmonary hypertension	University of British Columbia	Completed	No outcome recorded
Phase 4	NCT02703220	Jul 2015 → Jul 2026 overdue	sleep apnea syndrome	VA Office of Research and Development	Recruiting	No outcome recorded
Phase 4	NCT02427880	Apr → Jun 2015	nephrotic syndrome	Shiraz University of Medical Sciences	Completed	No outcome recorded
Phase 4	NCT02371473	Nov 2014 → Jun 2018	central sleep apnea syndrome	Shahid Beheshti University of Medical Sciences	Unknown	No outcome recorded
Phase 4	NCT01973335	Nov 2013 → Apr 2017	heart failure	Hasselt University	Completed	Missed primary
Phase 4	NCT01993667	Mar 2012 → Nov 2016	acute mountain sickness	University of Utah	Completed	No outcome recorded
Phase 4	NCT01535768	Feb 2012 → Jun 2018	glaucoma	Credit Valley EyeCare	Unknown	No outcome recorded
Phase 4	NCT00928655	Jun → Nov 2009	obstructive sleep apnea syndrome	University of Zurich	Completed	No outcome recorded
Phase 4	NCT00714740	Jun → Dec 2008	obstructive sleep apnea syndrome	University of Zurich	Completed	No outcome recorded
Phase 4	NCT00517426	Jul 2007 → Jul 2011	heart failure	Centro Cardiologico Monzino	Completed	No outcome recorded
Phase 4	NCT00485238	Feb 2007 → Dec 2008	glaucoma	National University Hospital, Singapore	Unknown	No outcome recorded
Phase 4	NCT00222534	Jan 2002 → Dec 2009	disorder of acid-base balance, respiratory failure	University of Oslo School of Pharmacy	Completed	No outcome recorded

Phase not applicable12 trials · 1 met primary · 1 missed
—	NCT06273397	May 2024 → Mar 2027 expected	symptomatic heart failure	Clinica Alemana de Santiago	Not yet recruiting	No outcome recorded
—	NCT04251364	Feb 2020 → Oct 2021	chronic mountain sickness	Centre d'Expertise sur l'Altitude EXALT	Completed	No outcome recorded
—	NCT03005665	Feb → Oct 2016	intracranial hypertension	Post Graduate Institute of Medical Education and Research, Chandigarh	Completed	No outcome recorded
—	NCT02670096	Jan → Dec 2016	sleep apnea syndrome	NYU Langone Health	Withdrawn	No outcome recorded
—	NCT03107429	Mar → Oct 2015	ocular hypertension	University of Nottingham	Completed	No outcome recorded
—	NCT01377987	Aug 2011 → Dec 2016	heart failure	David Andrew Wellman	Completed	No outcome recorded
—	NCT01288781	Jul → Aug 2011	acute mountain sickness	Bangor University	Completed	Missed primary
—	NCT01146288	Jul 2010 → May 2014	medulloadrenal hyperfunction	Rabin Medical Center	Completed	Met primary
—	NCT01131377	May 2010 → May 2011	disorder of acid-base balance	Asan Medical Center	Unknown	No outcome recorded
—	NCT00108602	May 2007	obstructive sleep apnea syndrome, stroke disorder	US Department of Veterans Affairs	Withdrawn	No outcome recorded
—	NCT00363571	Aug 2006 → May 2007	migraine disorder	Danish Headache Center	Unknown	No outcome recorded
—	NCT00497120	—	sleep apnea syndrome	University Hospital, Antwerp	Unknown	No outcome recorded

Comparator or background therapy71 trials
Phase 0	NCT07517068 Comparator	Sep 2025 → Jun 2026 overdue	acute mountain sickness	University of California, Riverside	Active not recruiting	No outcome recorded
Phase 0	NCT03525561 Comparator	Oct 2018 → May 2019	cognitive disorder	United States Army Research Institute of Environmental Medicine	Completed	No outcome recorded
Phase 0	NCT03963336 Comparator	Jul 2017 → Jul 2018	pseudotumor cerebri	Fayoum University	Completed	No outcome recorded
Phase 1	NCT04470843 Comparator	Aug 2018 → Mar 2021	prostate cancer	Medical College of Wisconsin	Completed	No outcome recorded
Phase 1	NCT03154645 Comparator	Aug → Oct 2017	acute mountain sickness	Grant S Lipman	Completed	No outcome recorded
Phase 1	NCT00780325 Comparator	Oct 2008 → Jul 2013	—	University of Pennsylvania	Terminated	No outcome recorded Stop: Business
Phase 1/2	NCT05293600 Comparator	Jul 2023 → Oct 2026 expected	obstructive sleep apnea syndrome	Brigham and Women's Hospital	Recruiting	No outcome recorded
Phase 1/2	NCT05589792 Comparator	Jan 2023 → Dec 2025	obstructive sleep apnea syndrome	Brigham and Women's Hospital	Completed	No outcome recorded
Phase 1/2	NCT04887792 Comparator	Feb 2022 → Dec 2027 expected	schizoaffective disorder, schizophrenia	Vishwajit Nimgaonkar, MD PhD	Recruiting	No outcome recorded
Phase 1/2	NCT01187108 Comparator	Jun → Sep 2013	chronic mountain sickness, polycythemia	University of Colorado, Denver	Completed	No outcome recorded
Phase 2	NCT07372040 Comparator	Feb 2026 → Feb 2027 expected	heart failure	Tanta University	Recruiting	No outcome recorded
Phase 2	NCT06776432 Comparator	Apr 2025 → Dec 2026 expected	sleep apnea syndrome	Shionogi	Active not recruiting	No outcome recorded
Phase 2	NCT05290948 Comparator	Mar → Jul 2022	macular retinal edema	Shahid Beheshti University of Medical Sciences	Unknown	No outcome recorded
Phase 2	NCT04975269 Comparator	Feb 2022 → Nov 2024	normal pressure hydrocephalus	Uppsala University Hospital	Completed	No outcome recorded
Phase 2	NCT03763227 Comparator	Jul 2015 → Aug 2019	inherited retinal dystrophy	Sultan Qaboos University	Completed	No outcome recorded
Phase 2	NCT02760901 Comparator	Nov 2013 → Oct 2015	cisplatin toxicity	Ain Shams University	Completed	No outcome recorded
Phase 2	NCT00634491 Comparator	Sep 2007 → Feb 2008	acute tubulointerstitial nephritis	Shiraz University of Medical Sciences	Completed	No outcome recorded
Phase 2/3	NCT06783166 Comparator	Aug 2024 → Jul 2025 overdue	heart failure	Mansoura University	Recruiting	No outcome recorded
Phase 2/3	NCT06146101 Comparator	May 2024 → Dec 2026 expected	obstructive sleep apnea syndrome	Incannex Healthcare Ltd	Active not recruiting	No outcome recorded
Phase 2/3	NCT02945527 Comparator	Dec 2015 → Dec 2018	cysticercosis	Universidad Peruana Cayetano Heredia	Terminated	No outcome recorded Stop: Enrollment
Phase 2/3	NCT01003639 Comparator	Jan 2010 → Jun 2013	pseudotumor cerebri	St. Luke's-Roosevelt Hospital Center	Completed	No outcome recorded
Phase 3	NCT06535529 Comparator	Aug 2024 → Aug 2025 overdue	heart failure	Helwan University	Recruiting	No outcome recorded
Phase 3	NCT05707442 Comparator	Feb 2023 → Jan 2027 expected	spontaneous intracranial hypotension	Beijing Tiantan Hospital	Recruiting	No outcome recorded
Phase 3	NCT04913389 Comparator	Jun 2021 → Aug 2022	altitude sickness, chronic obstructive pulmonary disease	University of Zurich	Unknown	No outcome recorded
Phase 3	NCT03501966 Comparator	Feb → Aug 2019	pseudotumor cerebri	Jaeb Center for Health Research	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT02604173 Comparator	Aug → Sep 2016	acute mountain sickness	Stanford University	Completed	Missed primary
Phase 3	NCT02163330 Comparator	Jun 2014 → Jan 2017	—	Rabin Medical Center	Terminated	No outcome recorded Stop: Enrollment
Phase 3	NCT00637468 Comparator	Sep 2002 → ?	central retinal artery occlusion, stroke disorder	University Hospital Freiburg	Terminated	No outcome recorded
Phase 4	NCT07101250 Comparator	Oct 2025 → Dec 2026 expected	myofascial pain syndrome	Prisma Health-Upstate	Recruiting	No outcome recorded
Phase 4	NCT06166654 Comparator	Sep 2024 → Sep 2027 expected	heart failure	Johannes Grand	Recruiting	No outcome recorded
Phase 4	NCT06498531 Comparator	Jul 2024 → Aug 2025	sleep apnea syndrome	University of Zurich	Completed	No outcome recorded
Phase 4	NCT06498505 Comparator	Jul 2024 → Aug 2025	altitude sickness	University of Zurich	Completed	No outcome recorded
Phase 4	NCT06499727 Comparator	Jul 2024 → Aug 2025	acute mountain sickness	University of Zurich	Completed	No outcome recorded
Phase 4	NCT05986773 Comparator	Oct 2023 → Dec 2024	heart failure	Stadtspital Zürich	Terminated	No outcome recorded Stop: Enrollment
Phase 4	NCT05575180 Comparator	Aug 2023 → Feb 2024	altitude sickness	University of Waterloo	Completed	No outcome recorded
Phase 4	NCT05904808 Comparator	Apr → Aug 2023	congestive heart failure	Rambam Health Care Campus	Completed	No outcome recorded
Phase 4	NCT04118387 Comparator	Jan 2021 → Dec 2026 expected	central sleep apnea syndrome	VA Office of Research and Development	Recruiting	No outcome recorded
Phase 4	NCT04227093 Comparator	Jan 2020 → Apr 2023	obstructive sleep apnea syndrome	University Hospital, Antwerp	Unknown	No outcome recorded
Phase 4	NCT03539367 Comparator	Jun 2018 → Dec 2022	altitude sickness	University of Zurich	Unknown	No outcome recorded
Phase 4	NCT03540914 Comparator	Jun 2018 → Dec 2024	altitude sickness	University of Zurich	Unknown	No outcome recorded
Phase 4	NCT03537924 Comparator	Jun 2018 → Dec 2022	altitude sickness	University of Zurich	Unknown	No outcome recorded
Phase 4	NCT03540901 Comparator	May → Aug 2018	chronic obstructive pulmonary disease	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03561675 Comparator	May 2018 → Aug 2019	acute mountain sickness	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03536429 Comparator	May → Aug 2018	altitude sickness	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03536455 Comparator	May → Aug 2018	altitude sickness	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03536520 Comparator	May → Aug 2018	altitude sickness	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03536507 Comparator	May → Aug 2018	altitude sickness	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03177811 Comparator	May 2017 → Aug 2018	chronic obstructive pulmonary disease	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03167034 Comparator	May 2017 → Aug 2018	chronic obstructive pulmonary disease	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03177837 Comparator	May 2017 → Aug 2018	chronic obstructive pulmonary disease	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03156231 Comparator	May 2017 → Aug 2018	chronic obstructive pulmonary disease	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03173508 Comparator	May 2017 → Aug 2018	chronic obstructive pulmonary disease	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03177850 Comparator	May 2017 → Aug 2018	chronic obstructive pulmonary disease	University of Zurich	Completed	No outcome recorded
Phase 4	NCT03165890 Comparator	May → Jul 2017	chronic obstructive pulmonary disease	University of Zurich	Completed	No outcome recorded
Phase 4	NCT01889498 Comparator	Jul 2014 → Jun 2016	thoracic aortic aneurysm	Liverpool Heart and Chest Hospital NHS Foundation Trust	Unknown	No outcome recorded
Phase 4	NCT01627639 Comparator	Oct 2011 → Jul 2014	chronic obstructive pulmonary disease	Assistance Publique - Hôpitaux de Paris	Completed	No outcome recorded
Phase 4	NCT01418157 Comparator	Aug → Oct 2011	acute mountain sickness	Oxford University Clinical Research Unit, Vietnam	Completed	No outcome recorded
Phase 4	NCT01228149 Comparator	Aug 2010 → Apr 2014	glaucoma	Katrin Lorenz	Completed	No outcome recorded
Phase 4	NCT00552526 Comparator	Nov 2007 → Jan 2011	epilepsy	Oslo University Hospital	Unknown	No outcome recorded
Phase 4	NCT00424970 Comparator	Jan → Nov 2007	polycythemia due to hypoxia	Association pour la Recherche en Physiologie de l'Environnement	Completed	No outcome recorded
—	NCT07707544 Comparator	Jun → Dec 2026 expected	pseudotumor cerebri	Sohag University	Active not recruiting	No outcome recorded
—	NCT06945848 Comparator	Jan 2026 → Jan 2029 expected	pseudotumor cerebri	University Hospital, Montpellier	Recruiting	No outcome recorded
—	NCT06919744 Comparator	Sep 2025 → Oct 2028 expected	pseudotumor cerebri	University Hospital, Montpellier	Recruiting	No outcome recorded
—	NCT06362668 Comparator	May → Oct 2024	heart failure	Reprieve Cardiovascular, Inc	Completed	No outcome recorded
—	NCT02972411 Comparator	Oct 2016 → May 2017	altitude sickness	Hospital del Trabajador de Santiago	Unknown	No outcome recorded
—	NCT01750723 Comparator	Dec 2012 → Apr 2013	migraine disorder	Danish Headache Center	Completed	No outcome recorded
—	NCT01519544 Comparator	Mar → Jul 2012	sleep disorder	Massachusetts General Hospital	Completed	No outcome recorded
—	NCT02140450 Comparator	Feb 2012 → Jan 2014	—	Mashhad University of Medical Sciences	Completed	No outcome recorded
—	NCT01060969 Background	Jan 2006 → Aug 2010	brain edema, pulmonary edema	Sheba Medical Center	Completed	No outcome recorded
—	NCT01923454 Background	Dec 2005 → Jun 2007	acute closed-angle glaucoma	Siriraj Hospital	Completed	No outcome recorded
—	NCT00120731 Background	Jul 2005 → May 2007	nephrolithiasis	Children's Mercy Hospital Kansas City	Withdrawn	No outcome recorded

News releases announcing trial results or a regulatory action · 4

Date	Issuer	Release
2025-06-02	Obsidian Therapeutics, Inc.	Results Obsidian Therapeutics Announces Positive Clinical Data from OBX-115 in Patients with Advanced Melanoma in Ongoing Multicenter Study at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting obsidiantx.com ↗ Acetazolamide (ACZ) redosing following initial OBX-115 infusion to drive re-activation of OBX-115 cells was tolerable and safe enough to administer at home.
2023-04-06	Zydus Lifesciences Limited	Regulatory Zydus receives final approval from the USFDA for Acetazolamide Tablets USP, 125 mg and 250 mg zyduslife.com ↗ Zydus Lifesciences Limited (including its subsidiaries/affiliates, hereafter referred to as “Zydus”) has received final approval from the United States Food and Drug Administration (USFDA) to manufacture and market Acetazolamide Tablets USP, 125 mg and 250 mg (USRLD: Diamox Tablets, 125 mg and 250 mg).
2019-04-17	Zydus Lifesciences Limited	Regulatory Zydus receives final approval from the USFDA for Acetazolamide for Injection zyduslife.com ↗
2019-01-17	Zydus Lifesciences Limited	Regulatory Zydus Receives Final Approval from The USFDA for Acetazolamide ER Capsules zyduslife.com ↗ Zydus Cadila has received the final approval from the USFDA to market Acetazolamide ER Capsules (US RLD – Diamox).

All press releases naming this drug 4 releases

Date	Issuer	Release
2025-06-02	Obsidian Therapeutics, Inc.	Obsidian Therapeutics Announces Positive Clinical Data from OBX-115 in Patients with Advanced Melanoma in Ongoing Multicenter Study at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting obsidiantx.com ↗
2023-04-06	Zydus Lifesciences Limited	Zydus receives final approval from the USFDA for Acetazolamide Tablets USP, 125 mg and 250 mg zyduslife.com ↗
2019-04-17	Zydus Lifesciences Limited	Zydus receives final approval from the USFDA for Acetazolamide for Injection zyduslife.com ↗
2019-01-17	Zydus Lifesciences Limited	Zydus Receives Final Approval from The USFDA for Acetazolamide ER Capsules zyduslife.com ↗

Evidence & citations 37 cited values

Every value below carries the sentence it was read from. 162 sources stand behind the page.

Field	Value	Cited text
Known as	Acetazolamide	“Drugs from ACT groups N03A, N05BA, N05CD, H02A or S01EC will be used including prednisolon,levetiracetam, valproate, carbamazepine, oxcarbazepine, topiramate, felbamate,...” NCT00552526 ↗ 157 “RESEARCH QUESTION: Is 2 weeks of 500 mg acetazolamide plus 100 mg atomoxetine daily effective for OHS severity (reduction in mean nocturnal CO2 as the primary outcome)?” PMID 41015199 ↗ Sep 2025 “On the other hand injection of Diamox (Acetazolamide) apparently causes increase of the cerebral blod flow with out dilation of the arteries.” NCT00363571 ↗ “Finally, stop the topical carbonic anhydrase inhibitor eye drop and start oral acetazolamide. (acetazolamide 250mg PO OD)” NCT01535768 ↗ “Acetazolamide will be introduced at the time of papilledema discovery.” NCT06919744 ↗ “Diamox (oral acetazolamide) starting 28 days Prior to trabeculectomy.” NCT01228149 ↗ “oral acetazolamide 500mg/day or topical brinzolamide twice daily” NCT03763227 ↗ “3. acetazolamide at a dose based on serum creatinine value” NCT04062760 ↗ NCT05575180 ↗ NCT00746954 ↗ NCT00780325 ↗ Show 147 more sources
Known as	Acetamox	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Acetazolamida	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Acetazolamide (Diamox 250 mg)	“Acetazolamide (Diamox 250 mg)” NCT01923454 ↗
Known as	acetazolamide = Zoladin	“acetazolamide = Zoladin” NCT01131377 ↗
Known as	ACETAZOLAMIDE SODIUM	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Acetazolamide sodium salt	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Acetazolamide, oral capsule	“Acetazolamide, oral capsule” NCT04915365 ↗
Known as	Acetazolamidum	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	ACTZ	“Acetazolamide (ACTZ) decreases serum bicarbonate concentration and stimulates respiratory drive.” PMID 28286047 ↗ Mar 2017
Known as	Acz	“Prophylaxis of AMS is primarily based on the administration of 250 mg/day of acetazolamide (ACZ), a carbonic anhydrase inhibitor with a mild diuretic effect.” NCT07118462 ↗ 1 “A preliminary study demonstrated the efficiency of acetazolamide (Acz) (250 mg/d for 3 wk) in reducing serum erythropoietin and hematocrit.” PMID 18388356 ↗ Apr 2008
Known as	Atenezo	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	AZT	“The carbonic anhydrase inhibitor acetazolamide (AZT) modulates blood pressure at high altitude and reduces sleep-disordered breathing in patients with obstructive sleep apnea (OSA).” PMID 29510792 ↗ Mar 2018
Known as	Defiltran	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Diamox	“To evaluate the additive value of tadalafil given together with Diamox (acetazolamide) in preventing acute mountain sickness in travelers to high altitude areas.” NCT01060969 ↗ 5 “Acetazolamide (Diamox) has been shown to reduce the production of CSF in clinical cases of raised intracranial pressure” NCT02163330 ↗ “Acetazolamide (Diamox®) is a diuretic that acts at a different location in the kidney compared to the loop diuretics.” NCT03505788 ↗ “Diamox (oral acetazolamide) starting 28 days Prior to trabeculectomy.” NCT01228149 ↗ “Diamox” NCT03963336 ↗ NCT00363571 ↗
Known as	Diamox (acetazolamide)	“Diamox (acetazolamide)” NCT01973335 ↗
Known as	Diamox (brand name for acetazolamide)	“Diamox (brand name for acetazolamide)” NCT05411991 ↗
Known as	Diamox sr	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Didoc	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Diuriwas	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Donmox	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Edemox	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Eytazox	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Glaupax	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	L 579486	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Nephramide	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	NSC-145177	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Phonurit	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Sodium acetazolamide	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Known as	Vetamox	ChEMBL registry synonym — accepted as the source's own label CHEMBL20 ↗
Action	Inhibit	“Carbonic anhydrase XII inhibitor” CHEMBL20 ↗ 4 “Carbonic anhydrase IV inhibitor” CHEMBL20 ↗ “Carbonic anhydrase II inhibitor” CHEMBL20 ↗ “Carbonic anhydrase I inhibitor” CHEMBL20 ↗ “a carbonic anhydrase inhibitor” NCT00000115 ↗
Modality	Small molecule	— CHEMBL20 ↗
Route	Oral	“oral acetazolamide sodium 500 mg” NCT00000115 ↗
Target	CA1	“Carbonic anhydrase I inhibitor” CHEMBL20 ↗
Target	CA12	“Carbonic anhydrase XII inhibitor” CHEMBL20 ↗
Target	CA2	“Carbonic anhydrase II inhibitor” CHEMBL20 ↗
Target	CA4	“Carbonic anhydrase IV inhibitor” CHEMBL20 ↗