drugset / Trial / NCT07372040
Add-on Diuretics in Acute Decompensated Heart Failure
RandomizedParallel-groupOpen-labelTreatment
Summary
The aim of this study is to compare the efficacy and safety of empagliflozin, acetazolamide, and metolazone as add-on therapies to loop diuretics in patients with acute decompensated heart failure.
Timeline
- Start
- 2026-02-01
- Primary completion
- 2027-02-01
- Completion
- 2027-02-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetazolamide | Small molecule | 500 mg | Oral |
| Comparator | Empagliflozin | Small molecule | 10 mg | Oral |
| Comparator | Metolazone | Small molecule | 5 mg | Oral |