drugset / Trial / NCT03561675
Effect of Acetazolamide on Acute Mountain Sickness in Lowlanders Older Than 40 Years
Phase 4
Completed
349 enrolled
University of Zurich
National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov · collab
RandomizedParallel-groupQuadruple-blindPrevention
Summary
Randomized, placebo controlled trial evaluating efficacy of acetazolamide in preventing acute mountain sickness in lowlanders older than 40 years travelling from 760 m to 3'100 m.
Timeline
- Start
- 2018-05-15
- Primary completion
- 2019-08-31
- Completion
- 2019-08-31
Publications
- Hafliger A, Buergin A, Mayer LC, Mademilov M, Lichtblau M, Sooronbaev T, Ulrich S, Bloch KE, Furian M. Sex-Specific Difference in Health-Related Altitude-Effects and Their Prevention by Acetazolamide. Data from a Randomized Controlled Trial. High Alt Med Biol. 2025 Jun;26(2):195-203. doi: 10.1089/ham.2024.0011. Epub 2025 Jan 8.
- Furian M, Mademilov M, Buergin A, Scheiwiller PM, Mayer L, Schneider S, Emilov B, Lichtblau M, Bitos K, Muralt L, Groth A, Reiser AE, Sevik A, Sheraliev U, Marazhapov NH, Aydaralieva S, Muratbekova A, Tabyshova A, Abdraeva A, Buenzli S, Sooronbaev TM, Ulrich S, Bloch KE. Acetazolamide to Prevent Adverse Altitude Effects in COPD and Healthy Adults. NEJM Evid. 2022 Jan;1(1):EVIDoa2100006. doi: 10.1056/EVIDoa2100006. Epub 2021 Dec 22.
- Graf LC, Furian M, Bitos K, Mademilov M, Abdraeva A, Buenzli J, Buenzli S, Aidaralieva S, Sheraliev U, Mayer LC, Schneider SR, Sooronbaev TM, Ulrich S, Bloch KE. Effect of altitude and acetazolamide on sleep and nocturnal breathing in healthy lowlanders 40 y of age or older. Data from a randomized trial. Sleep. 2023 Apr 12;46(4):zsac269. doi: 10.1093/sleep/zsac269.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetazolamide | Small molecule | 375 mg | Oral |