Effect of Acetazolamide on Intraocular Pressure After Being in the Trendelenburg Position.

Summary

Perioperative vision loss following laparoscopic colorectal surgery is rare but has been reported. Studies show Trendelenburg positioning during surgery can produce a significant rise in the IOP, and this rise is thought to be a possible factor. Acetazolamide decreases IOP by reducing the formation of aqueous humour. Aims: To investigate if acetazolamide reduces the IOP rise resulting from Trendelenburg positioning. Methods: A randomised cross-over blinded pilot study. Nine healthy volunteers were randomised to start with the placebo or Acetazolamide with a 5 days' washout period. Baseline IOP was measured on both days. After 1.5 hours of taking the medication, volunteers lay head-down at 17 degrees' for 4 hours and IOP measurements repeated. This reading was subtracted from the baseline to give a 'change in IOP'.

Timeline

Start

2015-03-01

Primary completion

2015-10-01

Completion

2015-10-01

Drugs

Indications