TACTIC-HF: Sequential Diuretic Strategies in Ambulatory Worsening Heart Failure

Phase 4 Not yet recruiting 60 enrolled Lucrecia Maria Burgos

RandomizedCrossoverOpen-labelTreatment

Summary

TACTIC-HF is a prospective randomized crossover trial designed to compare three ambulatory diuretic strategies in patients with worsening heart failure treated in a specialized heart failure day-hospital program. Participants will receive sequential treatment with: 1. intravenous furosemide alone, 2. intravenous furosemide combined with oral acetazolamide, and 3. intravenous furosemide combined with oral hydrochlorothiazide. The primary objective is to compare short-term natriuretic response between strategies. Secondary objectives include assessment of urine output, congestion parameters, and renal/electrolyte safety. Each participant will undergo repeated outpatient treatment sessions separated by washout periods, with standardized clinical and laboratory monitoring performed during each visit. The study aims to evaluate pragmatic and clinically applicable ambulatory decongestion strategies using approved therapies commonly available in real-world practice.

Timeline

Start: 2026-06-15
Primary completion: 2027-01-15
Completion: 2027-01-15

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Acetazolamide	Small molecule	—	Oral
Subject	Hydrochlorothiazide	Unknown	—	Oral
Background	Furosemide	Other / unclassified	—	Intravenous

TACTIC-HF: Sequential Diuretic Strategies in Ambulatory Worsening Heart Failure

Summary

Timeline

Publications

Drugs

Indications