Muscle Fatigue and Carbonic Anhydrase Inhibitors

Phase 4 Completed 13 enrolled University of British Columbia

RandomizedCrossoverDouble-blindBasic science

Summary

The objective of this research is to assess the effects of acetazolamide and methazolamide on respiratory and limb muscle fatigue development. A fatiguing protocol will be conducted for the respiratory and plantar flexor muscles and the difference in pressure/torque produced by supramaximal nerve stimulation used to assess muscle fatigue between conditions.

Timeline

Start: 2016-11
Primary completion: 2017-06-30
Completion: 2017-06-30

Publications

Results Dominelli PB, McNeil CJ, Vermeulen TD, Stuckless TJR, Brown CV, Dominelli GS, Swenson ER, Teppema LJ, Foster GE. Effect of acetazolamide and methazolamide on diaphragm and dorsiflexor fatigue: a randomized controlled trial. J Appl Physiol (1985). 2018 Sep 1;125(3):770-779. doi: 10.1152/japplphysiol.00256.2018. Epub 2018 May 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Acetazolamide	Small molecule	250 mg	Oral
Subject	Methazolamide	Small molecule	100 mg	Oral

Indications

No indication recorded.