drugset / Trial / NCT05986773

Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance

NCT05986773

RandomizedParallel-groupOpen-labelTreatment

Summary

The P-VALUE-AHF trial is a multicenter, randomized, open-label, parallel-group trial on the diuretic and decongestive effects of different diuretic escalation strategies in patients with acute heart failure and diuretic resistance. The main aims are * to compare the diuretic efficacy of three therapeutic strategies in patients with acute heart failure and diuretic resistance. * to assess the improvement in clinical congestion and to compare the symptom-relief among the different treatment regimens

Timeline

Start
2023-10-10
Primary completion
2024-12-31
Completion
2024-12-31

Drugs

EvaluationDrugModalityDoseRoute
Comparator Acetazolamide Small molecule 500 mg Intravenous
Comparator Furosemide Other / unclassified 40 mg Intravenous
Comparator Metolazone Small molecule 5 mg Oral

Indications