drugset / Trial / NCT05986773
Diuretic Strategies in Acute Heart Failure Patients at High Risk for Diuretic Resistance
RandomizedParallel-groupOpen-labelTreatment
Summary
The P-VALUE-AHF trial is a multicenter, randomized, open-label, parallel-group trial on the diuretic and decongestive effects of different diuretic escalation strategies in patients with acute heart failure and diuretic resistance. The main aims are * to compare the diuretic efficacy of three therapeutic strategies in patients with acute heart failure and diuretic resistance. * to assess the improvement in clinical congestion and to compare the symptom-relief among the different treatment regimens
Timeline
- Start
- 2023-10-10
- Primary completion
- 2024-12-31
- Completion
- 2024-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetazolamide | Small molecule | 500 mg | Intravenous |
| Comparator | Furosemide | Other / unclassified | 40 mg | Intravenous |
| Comparator | Metolazone | Small molecule | 5 mg | Oral |