drugset

drugset / Trial / NCT03173508

Effect of Acetazolamide on Right Ventricular Function at Rest in Patients With Respiratory Disease at Altitude

NCT03173508 ↗

Phase 4 Completed 110 enrolled University of Zurich National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov · collab

RandomizedParallel-groupQuadruple-blindPrevention

Summary

This trial will evaluate the effect of acetazolamide (375 mg per day) vs. placebo on right ventricular function at acute altitude exposure in patients with COPD.

Timeline

Start: 2017-05-24
Primary completion: 2018-08-02
Completion: 2018-08-02

Publications

Preiss H, Mayer L, Furian M, Schneider SR, Muller J, Saxer S, Mademilov M, Titz A, Shehab A, Reimann L, Sooronbaev T, Tanner FC, Bloch KE, Ulrich S, Lichtblau M. Right ventricular strain impairment due to hypoxia in patients with COPD: a post hoc analysis of two randomised controlled trials. Open Heart. 2025 Jan 4;12(1):e002837. doi: 10.1136/openhrt-2024-002837.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Acetazolamide	Small molecule	375 mg	Oral

Indications