drugset / Trial / NCT01855360

Doxycycline and TUDCA in Patients With Transthyretin Amyloid Cardiomyopathy

NCT01855360

Phase 1/2 Completed 40 enrolled Brigham and Women's Hospital
NaSingle-groupOpen-labelTreatment

Summary

The objective of the study is to determine whether the combination of the bile acid TUDCA, and doxycycline will slow the progression of familial and senile amyloidosis.

Timeline

Start
2013-06
Primary completion
2015-05-31
Completion
2015-05-31

Drugs

EvaluationDrugModalityDoseRoute
Subject Doxycycline Small molecule 100 mg Oral
Subject Doxycycline Small molecule 200 mg Oral
Subject Taurursodiol Small molecule 250 mg Oral

Indications