The Effect of the Forced Diuresis With Matched Hydration in Reducing Acute Kidney Injury During TAVI

Summary

Evaluating whether forced diuresis with matched hydration will reduce the risk of contrast induced nephropathy in patients undergoing Transcatheter Aortic Valve Implantation (TAVI).

Timeline

Start

2013-06-01

Primary completion

2019-04-01

Completion

2019-05-22

Publications

• Hashimoto H, Yamada H, Murata M, Watanabe N. Diuretics for preventing and treating acute kidney injury. Cochrane Database Syst Rev. 2025 Jan 29;1(1):CD014937. doi: 10.1002/14651858.CD014937.pub2.
• Arbel Y, Ben-Assa E, Puzhevsky D, Litmanowicz B, Galli N, Chorin E, Halkin A, Sadeh B, Konigstein M, Bassat OK, Steinvil A, Bazan S, Banai S, Finkelstein A. Forced diuresis with matched hydration during transcatheter aortic valve implantation for Reducing Acute Kidney Injury: a randomized, sham-controlled study (REDUCE-AKI). Eur Heart J. 2019 Oct 7;40(38):3169-3178. doi: 10.1093/eurheartj/ehz343.
• Arbel Y, Ben-Assa E, Halkin A, Keren G, Schwartz AL, Havakuk O, Leshem-Rubinow E, Konigstein M, Steinvil A, Abramowitz Y, Finkelstein A, Banai S. Forced diuresis with matched hydration in reducing acute kidney injury during transcatheter aortic valve implantation (Reduce-AKI): study protocol for a randomized sham-controlled trial. Trials. 2014 Jul 2;15:262. doi: 10.1186/1745-6215-15-262.

Drugs

Indications