Ondansetron Administration to WELL Children With Gastroenteritis Associated Vomiting in EDs in Pakistan

Summary

The primary objective is to determine if the administration of a single dose of oral ondansetron (an anti-vomiting medication), compared to placebo, results in a reduction in intravenous (IV) rehydration therapy in children presenting for emergency department care with vomiting and diarrhea in Pakistan.

Timeline

Start

2014-05

Primary completion

2017-01-20

Completion

2017-02-03

Outcome

Missed primary endpoint

paper CONCLUSION: Oral administration of a single dose of ondansetron did not result in a reduction in intravenous rehydration use. PMID 30392735 ↗

Publications

• Freedman SB, Soofi SB, Willan AR, Williamson-Urquhart S, Ali N, Xie J, Dawoud F, Bhutta ZA. Oral Ondansetron Administration to Nondehydrated Children With Diarrhea and Associated Vomiting in Emergency Departments in Pakistan: A Randomized Controlled Trial. Ann Emerg Med. 2019 Mar;73(3):255-265. doi: 10.1016/j.annemergmed.2018.09.011. Epub 2018 Nov 2.

Drugs

Indications