Metformin at the Cellular Level and Dosing for Diabetes Mellitus (DM)

Summary

The investigators know that metformin works at the level of the cells in the body by acting on a protein called Cyclic amine monophosphate- Response Binding Elements (CREB) binding protein or Constitutive Reverter of eIF2α Phosphorylation (CREP) Binding Protein (CBP). What the investigators do not know is how this process is affected when the dose of the metformin is increased or changed. Currently the same doses of metformin are often used in both children and adults, but it is possible that the dose of metformin should be based on age and weight. Understanding how CBP works could potentially help us to tailor metformin treatment individually for patients based on their age, weight and CBP response.

Timeline

Start

2012-01

Primary completion

2015-06

Completion

2015-06

Outcome

Outcome not reported

Stopped: “All investigators/co-investigators relocating to other institutions.”

Drugs

Indications