Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease

Summary

The objective of this study is to assess the effect of alkali administration on bicarbonate and potassium levels in patients with Sickle Cell Disease (SCD) and depressed serum bicarbonate levels. The study is a prospective non-blinded evaluation of tolerability and efficacy of alkali repletion with 4 weeks of observation and two sequential 4 week courses of escalating oral sodium bicarbonate treatment.

Timeline

Start

2013-06

Primary completion

2019-03

Completion

2019-03

Drugs

Indications