drugset / Trial / NCT01908478

Veliparib in Combination With Gemcitabine and Intensity Modulated Radiation Therapy in Patients With Pancreatic Cancer

NCT01908478

Phase 1 Completed 34 enrolled Cedars-Sinai Medical Center AbbVie · collab
NaSingle-groupOpen-labelTreatment

Summary

This is a Phase I Study of veliparib (ABT-888) in combination with Gemcitabine and Intensity Modulated Radiation Therapy in Patients with Locally Advanced, Unresectable Pancreatic Cancer. Primary Objectives: * Determine the maximum tolerable dose of veliparib in combination with gemcitabine and intensity modulated radiation therapy in patients with locally advanced pancreatic cancer. * Determine the safety and toxicity of the combination of veliparib with gemcitabine and radiation therapy in patients with locally advanced pancreatic cancer

Timeline

Start
2013-10-02
Primary completion
2017-07-14
Completion
2020-07-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Veliparib Small molecule 20 mg
Background Gemcitabine Small molecule 1000 mg/m2 Intravenous