Drugs / Veliparib
last change Aug 2026 re-read 2 minutes ago

Veliparib

Small molecule targets PARP1 via inhibition

Developed for
triple-negative breast carcinoma · breast cancer · ovarian cancer · primary peritoneal carcinoma · BRCA1-related cancer predisposition · BRCA2-related cancer predisposition · cancer · ovarian carcinoma
+172 more · fallopian tube carcinoma · neoplasm · non-small cell lung carcinoma · colorectal cancer · female breast carcinoma · small cell lung carcinoma · cancer of unknown primary site · chronic myelomonocytic leukemia · fallopian tube cancer · gastric cancer · hereditary breast carcinoma · lymphoma · male breast carcinoma · metastatic malignant neoplasm · pancreatic adenocarcinoma · acquired polycythemia vera · acute myeloid leukemia, inv(16)(p13.1;q22) · acute myeloid leukemia, t(16;16)(p13.1;q22) · acute myeloid leukemia, t(8;21)(q22; q22.1) · acute myeloid leukemia, t(9;11)(p21.3;q23.3) · anaplastic astrocytoma · B-cell adult acute lymphocytic leukemia · brain stem glioma · breast carcinoma · central nervous system neoplasm · cervical adenosquamous carcinoma · essential thrombocythemia · gliosarcoma · hepatocellular carcinoma · hereditary breast ovarian cancer syndrome · lung cancer · lung large cell carcinoma · malignant pancreatic neoplasm · mantle cell lymphoma · mixed glioma · ovarian endometrioid adenocarcinoma · ovarian serous adenocarcinoma · plasma cell myeloma · undifferentiated ovarian carcinoma · acute megakaryoblastic leukemia in adult · acute myeloblastic leukemia with maturation · acute myeloblastic leukemia without maturation · acute myeloid leukemia · acute myeloid leukemia and myelodysplastic syndromes related to alkylating agent · acute myeloid leukemia with minimal differentiation · acute myeloid leukemia, t(15;17)(q24;q21) · acute myelomonocytic leukemia M4 · adrenal cortex carcinoma · adult acute lymphoblastic leukemia · adult acute monocytic leukemia · adult T-cell leukemia/lymphoma · anaplastic large cell lymphoma · angioimmunoblastic T-cell lymphoma · astrocytoma (excluding glioblastoma) · atypical chronic myeloid leukemia, BCR-ABL1 negative · atypical teratoid rhabdoid tumor · B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) · basal-like breast carcinoma · benign meningioma · bladder transitional cell carcinoma · brain neoplasm · Burkitt lymphoma · carcinoma of esophagus · castration-resistant prostate carcinoma · cervical small cell carcinoma · childhood brain stem glioma · childhood central nervous system germ cell tumor · childhood cerebellar astrocytic neoplasm · childhood cerebral astrocytoma · childhood choroid plexus neoplasm · childhood medulloblastoma · childhood oligodendroglioma · childhood spinal cord tumor · chronic lymphocytic leukemia/small lymphocytic lymphoma · chronic myeloid leukemia · craniopharyngioma · cutaneous neuroendocrine carcinoma · endometrial carcinoma · ependymoblastoma · ependymoma · erythroleukemia · estrogen-receptor positive breast cancer · extrahepatic bile duct carcinoma · extranodal nasal NK/T cell lymphoma · fallopian tube carcinosarcoma · fallopian tube clear cell adenocarcinoma · fallopian tube endometrioid adenocarcinoma · fallopian tube mucinous adenocarcinoma · fallopian tube transitional cell carcinoma · gallbladder carcinoma · gastric adenocarcinoma · glioblastoma · glucagonoma · grade II meningioma · grade III lymphomatoid granulomatosis · grade III meningioma · hairy cell leukemia · head and neck cancer · head and neck squamous cell carcinoma · hepatosplenic T-cell lymphoma · hereditary neoplastic syndrome · high grade malignant neoplasm · Hodgkin's lymphoma, mixed cellularity · intraocular lymphoma · large-cell immunoblastic lymphoma · leukemia · lung carcinoma · malignant adrenal gland pheochromocytoma · malignant epithelial tumor of ovary · MALT lymphoma · medullary thyroid gland carcinoma · medulloblastoma · medulloepithelioma · melanoma · metastatic malignant neoplasm in the brain · metastatic melanoma · metastatic neoplasm · minimally invasive lung adenocarcinoma · multiple endocrine neoplasia type 1 · multiple endocrine neoplasia type 2A · multiple endocrine neoplasia type 2B · mycosis fungoides and variants · myelodysplastic syndrome · myelofibrosis · nodal marginal zone B-cell lymphoma · non-functional pancreatic neuroendocrine tumor · non-small cell squamous lung carcinoma · optic pathway glioma · oropharyngeal carcinoma · ovarian Brenner tumor · ovarian carcinosarcoma · ovarian clear cell adenocarcinoma · ovarian clear cell cystadenocarcinoma · ovarian germ cell tumor · ovarian mucinous adenocarcinoma · ovarian mucinous cystadenocarcinoma · ovarian seromucinous carcinoma · ovarian seromucinous tumor · ovarian serous cystadenocarcinoma · ovarian transitional cell carcinoma · pancreas disorder · pancreatic insulinoma · pediatric infratentorial ependymoma · pediatric supratentorial ependymoma · peritoneal carcinomatosis · pineoblastoma · primary cutaneous B-cell lymphoma · primary organ-specific lymphoma · primary peritoneal serous adenocarcinoma · primitive neuroectodermal tumor · prostate cancer · prostate carcinoma · rectal carcinoma · rectum adenocarcinoma · renal pelvis/ureter urothelial carcinoma · serous adenocarcinoma · small intestine lymphoma · somatostatinoma · splenic marginal zone lymphoma · squamous cell lung carcinoma · subependymal giant cell astrocytoma · supratentorial primitive neuroectodermal tumor · T-cell adult acute lymphocytic leukemia · T-cell non-Hodgkin lymphoma · testicular cancer · testicular germ cell tumor · testicular lymphoma · thymic neuroendocrine tumor · urothelial carcinoma · VIPoma · Waldenstrom macroglobulinemia · Zollinger-Ellison syndrome
Investigated by
National Cancer Institute (NCI) · AbbVie · AbbVie · Abbott · NRG Oncology · Georgetown University
+29 more · University of Washington · Vejle Hospital · AHS Cancer Control Alberta · Australia New Zealand Gynaecological Oncology Group · Beth Israel Deaconess Medical Center · Breast Cancer Research Foundation of Alabama · Bristol-Myers Squibb · Cedars-Sinai Medical Center · Central European Society for Anticancer Drug Research · Dana-Farber Cancer Institute · Dutch Cancer Society · GlaxoSmithKline · National Cancer Institute, Slovakia · National Institutes of Health Clinical Center (CC) · Northwestern University · Prostate Cancer Clinical Trials Consortium · QuantumLeap Healthcare Collaborative · Radiation Therapy Oncology Group · Richard Zellars · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University · Steven J Isakoff, MD, PhD · Susan G. Komen Breast Cancer Foundation · The University of Texas Health Science Center at San Antonio · Tom Baker Cancer Centre · University Medical Center Groningen · University of Alabama at Birmingham · University of Michigan Rogel Cancer Center · Vanderbilt-Ingram Cancer Center

Trials 99 · started per year

today
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PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 153 trials
Phase 1 NCT03400306 Nov 2021 ovarian cancer AbbVie Withdrawn No outcome recorded
Phase 1 NCT02831179 Dec 2017 → Feb 2019 VIPoma, Zollinger-Ellison syndrome, adrenal cortex carcinoma, cutaneous neuroendocrine carcinoma +10 Vanderbilt-Ingram Cancer Center Withdrawn No outcome recorded
Phase 1 NCT02723864 Aug 2017 → Dec 2020 neoplasm National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT02631733 May 2017 → Nov 2019 cancer National Cancer Institute (NCI) Completed No outcome recorded
Phase 1 NCT03061188 May 2017 → Mar 2018 T-cell non-Hodgkin lymphoma, high grade malignant neoplasm, mantle cell lymphoma Northwestern University Completed No outcome recorded
Phase 1 NCT02944396 Dec 2016 → Oct 2019 non-small cell lung carcinoma AbbVie Completed No outcome recorded
Phase 1 NCT03227016 Oct 2016 → May 2021 small cell lung carcinoma Central European Society for Anticancer Drug Research Unknown No outcome recorded
Phase 1 NCT02483104 Jul 2015 → Mar 2016 ovarian cancer AbbVie Completed No outcome recorded
Phase 1 NCT02210663 Jul 2014 → Jan 2016 cancer AbbVie Completed No outcome recorded
Phase 1 NCT02033551 Dec 2013 → Sep 2016 breast cancer, colorectal cancer, gastric cancer, lung cancer +1 AbbVie Completed No outcome recorded
Phase 1/212 trials
Phase 1/2 NCT02412371 Apr 2015 → Aug 2019 non-small cell lung carcinoma AbbVie Terminated No outcome recorded
Phase 1/2 NCT02289690 Oct 2014 → Apr 2019 small cell lung carcinoma AbbVie Completed No outcome recorded
Phase 1/2 NCT01690598 Nov 2012 → Jan 2015 ovarian carcinoma Vejle Hospital Completed No outcome recorded
Phase 1/2 NCT01711541 Oct 2012 → Feb 2018 head and neck squamous cell carcinoma, oropharyngeal carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT01642251 Sep 2012 → Dec 2016 lung large cell carcinoma, small cell lung carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT01514201 Feb 2012 → Mar 2018 anaplastic astrocytoma, brain stem glioma, fibrillary astrocytoma, giant cell glioblastoma +2 National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT01472783 Nov 2011 → Jan 2016 malignant epithelial tumor of ovary Vejle Hospital Completed No outcome recorded
Phase 1/2 NCT01326702 Jul 2011 → Apr 2015 B-cell adult acute lymphocytic leukemia, Burkitt lymphoma, Hodgkin's lymphoma, mixed cellularity, MALT lymphoma +19 National Cancer Institute (NCI) Completed No outcome recorded
Phase 1/2 NCT01386385 Jun 2011 → May 2019 overdue lung large cell carcinoma, minimally invasive lung adenocarcinoma, squamous cell lung carcinoma National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 1/2 NCT01489865 Jan 2011 → Dec 2018 malignant pancreatic neoplasm Georgetown University Completed No outcome recorded
Phase 227 trials
Phase 2 NCT03044795 Nov 2019 → Nov 2020 cancer University Medical Center Groningen Withdrawn No outcome recorded
Phase 2 NCT03581292 Nov 2018 → Mar 2023 overdue anaplastic astrocytoma, glioblastoma National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 2 NCT03289910 Sep 2018 → May 2023 overdue acquired polycythemia vera, acute myeloid leukemia, atypical chronic myeloid leukemia, BCR-ABL1 negative, chronic myelomonocytic leukemia +2 National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 2 NCT03032614 Sep 2017 → Mar 2019 BRCA1-related cancer predisposition, BRCA2-related cancer predisposition, breast cancer, ovarian cancer The University of Texas Health Science Center at San Antonio Withdrawn No outcome recorded
Phase 2 NCT02921256 Jan 2017 → Apr 2020 rectum adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT02890355 Oct 2016 → May 2019 pancreatic adenocarcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT02595905 Sep 2016 → Jan 2025 hereditary breast carcinoma, metastatic malignant neoplasm in the brain, triple-negative breast carcinoma National Cancer Institute (NCI) Completed No outcome recorded
Phase 2 NCT02860819 Aug 2016 → Nov 2020 testicular germ cell tumor National Cancer Institute, Slovakia Completed No outcome recorded
Phase 2 NCT02305758 Dec 2014 → Sep 2017 colorectal cancer AbbVie Completed No outcome recorded
Phase 2 NCT01827384 Jan 2014 → Jun 2021 cancer National Cancer Institute (NCI) Completed No outcome recorded
Phase 2/31 trial
Phase 2/3 NCT02152982 Dec 2014 → Dec 2021 overdue gliosarcoma National Cancer Institute (NCI) Active not recruiting No outcome recorded
Phase 34 trials
Phase 3 NCT02470585 Jul 2015 → May 2019 ovarian cancer AbbVie Terminated No outcome recorded
Phase 3 NCT02264990 Sep 2014 → Nov 2019 non-small cell lung carcinoma AbbVie Completed No outcome recorded
Phase 3 NCT02106546 Apr 2014 → Jan 2017 non-small cell squamous lung carcinoma AbbVie Completed No outcome recorded
Phase 3 NCT02163694 Apr 2014 → Apr 2019 breast cancer AbbVie Completed No outcome recorded
Phase not applicable1 trial
NCT02158507 Sep 2014 → Jul 2021 triple-negative breast carcinoma University of Alabama at Birmingham Completed No outcome recorded
Phase not stated1 trial
NCT02985658 hereditary breast carcinoma, triple-negative breast carcinoma University of Washington No longer available No outcome recorded
Also used as a comparator or background therapy in 3 trials
PhaseRegistry idDatesIndicationSponsorStatusOutcome
Phase 21 trial
Phase 2 NCT00804908 Comparator Feb 2009 → Jan 2016 metastatic melanoma, skin cancer AbbVie Completed No outcome recorded
Phase 31 trial
Phase 3 NCT02032277 Comparator Apr 2014 → Mar 2016 triple-negative breast carcinoma AbbVie Completed No outcome recorded
Phase not stated1 trial
NCT03123211 Background ovarian serous adenocarcinoma, triple-negative breast carcinoma AbbVie No longer available No outcome recorded

Press releases naming this drug 5 releases

DateIssuerRelease
2017-04-19 AbbVie AbbVie Announces Topline Results from Two Phase 3 Studies Investigating Veliparib in Combination with Chemotherapy for the Treatment of Patients with Advanced or Metastatic Squamous Non-Small Cell Lung Cancer and Early-Stage Triple-Negative Breast Cancer abbvie.com
2016-11-04 AbbVie AbbVie Receives FDA Orphan Drug Designation for Investigational Medicine Veliparib for the Treatment of Advanced Squamous Non-Small Cell Lung Cancer abbvie.com
2015-06-01 AbbVie AbbVie Presents Phase 2 Results from Study of Investigational Medicine Veliparib in Patients with Non-Small Cell Lung Cancer at the American Society of Clinical Oncology Annual Meeting abbvie.com
2014-04-15 AbbVie AbbVie Announces Initiation of Pivotal Phase III Study of Veliparib (ABT-888) for Patients with Non-Small Cell Lung Cancer abbvie.com
2014-01-15 AbbVie AbbVie Announces Initiation of Pivotal Phase 3 Study of Veliparib (ABT-888) for Patients with Early-Stage Triple-Negative Breast Cancer abbvie.com

Evidence & citations 11 cited values

Every value below carries the sentence it was read from. 108 sources stand behind the page.

FieldValueCited text
Known as veliparib “The experimental cancer treatment drug ABT-888 (Veliparib) works by preventing deoxyribonucleic acid (DNA) repair in tumor cells.” NCT01306032
87

“A phase I trial of ABT-888 (veliparib), a PARP inhibitor, in combination with topotecan” PMID 21795476 Jul 2011

“ABT-888 (Veliparib)” NCT01495351

NCT03044795

NCT01123876

NCT00387608

NCT01477489

NCT00770471

NCT01540565

NCT01193140

NCT01104259

NCT02412371

NCT00740805

NCT01472783

NCT03061188

NCT02470585

NCT02033551

NCT03227016

NCT03400306

NCT01589419

NCT03581292

NCT01149083

NCT01251874

NCT00576654

NCT01853306

NCT02032277

NCT01233505

NCT02890355

NCT01063816

NCT02831179

NCT01266447

NCT00989651

NCT02944396

NCT02264990

NCT03032614

NCT01281150

NCT01012817

NCT02289690

NCT01434316

NCT01908478

NCT01827384

NCT01366144

NCT02860819

NCT00946335

NCT02163694

NCT02631733

NCT01145430

NCT01154426

NCT02009631

NCT03123211

NCT02106546

NCT01326702

NCT02210663

NCT01576172

NCT01638546

NCT01749397

NCT01282333

NCT01351909

NCT02158507

NCT01711541

NCT01690598

NCT02483104

NCT00588991

NCT01139970

NCT02985658

NCT01506609

NCT01617928

NCT01585805

NCT01386385

NCT01281852

NCT02723864

NCT01618357

NCT00892736

NCT00535119

NCT01514201

NCT01459380

NCT01818063

NCT01560104

NCT01657799

NCT01017640

NCT03289910

NCT02921256

NCT02595905

NCT01642251

NCT02152982

NCT02305758

NCT01199224

NCT01264432

Known as ABT-888 “Veliparib (ABT-888) is a potent PARP 1/2 inhibitor with clinical evidence of potentiation of antitumor activity in combination with cisplatin in breast cancer gene (BRCA)...” NCT02723864
29

“PRIMARY OBJECTIVES: I. To determine the maximum tolerated dose (MTD) of veliparib (ABT-888) in combination with capecitabine and temozolomide in patients with advanced...” NCT02831179

“The purpose of this study is to investigate the effect of combined topotecan and veliparib (ABT888) treatment in relapsed ovarian cancer with tumor progression and negative or...” NCT01690598

“A phase 1 study evaluating the pharmacokinetics and preliminary efficacy of veliparib (ABT-888) in combination with carboplatin/paclitaxel in Japanese subjects with non-small...” PMID 26433581 Oct 2015

“Phase II Study With PARP Inhibitor Veliparib (ABT-888) in Patients With Increased Risk of Homologous Recombination Deficiency to Determine the Value of an (Ex-vivo) RAD51 Assay...” NCT03044795

“Veliparib (ABT888) Monotherapy for Patients With BRCA Germline Mutation and Platinum-Resistant or Partially Platinum-Sensitive Relapse of Epithelial Ovarian Cancer” NCT01472783

“PURPOSE: Veliparib (ABT-888) is an orally bioavailable potent inhibitor of poly(ADP-ribose) polymerase (PARP)-1 and PARP-2.” PMID 27709282 Oct 2016

“This study assessed the efficacy and safety of low dose oral PARP inhibitor veliparib (ABT-888) and temozolomide (TMZ)” PMID 24764124 Apr 2014

“Development of a Level A in Vitro-in Vivo Correlation for Veliparib (ABT-888) Extended Release Tablet Formulation.” PMID 28243955 Feb 2017

“To determine the maximum-tolerated dose (MTD) of ABT-888 (veliparib) in combination with bendamustine” NCT01326702

ABT-888 (veliparib) 10 mg administered orally twice a day on days 1 to 5” NCT01266447

“veliparib (ABT-888)” NCT01063816

ABT-888NCT01711541

ABT-888NCT01154426

NCT01306032

NCT01051596

NCT00526617

NCT01495351

NCT00994071

NCT00553189

NCT00649207

NCT01445522

NCT01042379

NCT01205828

NCT01419548

NCT01026493

NCT01009788

NCT01113957

NCT00804908

NCT01489865

Known as ABT-888, veliparib ABT-888, veliparibNCT01113957
1

ABT-888, veliparibNCT01085422

Known as NSC 737664 “veliparib (ABT-888) (NSC 737664)” NCT01149083
Known as PARP-1 INHIBITOR ABT-888 ChEMBL registry synonym — accepted as the source's own label CHEMBL506871
Known as UNII-01O4K0631N ChEMBL registry synonym — accepted as the source's own label CHEMBL506871
Known as Veliparib (ABT-888) Veliparib (ABT-888)NCT02158507
Action Inhibit “ABT-888 is an oral PARP inhibitor” NCT00553189
Modality Small molecule CHEMBL506871
Route Oral “veliparib orally (PO)” NCT00535119
Target PARP1 “To develop assays to detect trapping of PARP1 and 2 in tumor biopsy tissue in response to treatment with irinotecan plus a PARP inhibitor, in this case ABT-888.” NCT00576654