The Safety and Efficiency of Propranolol as an Initial Treatment for Pediatric Hemangioma

Summary

The purpose of this study is to determine the safety and efficiency of Propranolol as an initial treatment for pediatric hemangioma.

Timeline

Start

2013-06

Primary completion

2015-05

Completion

2015-05

Outcome

Met primary endpoint

paper Because the difference in response rate between the groups was 3.71%, propranolol was considered noninferior. PMID 28423174 ↗

paper Our trial demonstrated that propranolol was not inferior to steroid with respect to therapeutic effects in IH. PMID 28423174 ↗

Publications

• Kim KH, Choi TH, Choi Y, Park YW, Hong KY, Kim DY, Choe YS, Lee H, Cheon JE, Park JB, Park KD, Kang HJ, Shin HY, Jeong JH. Comparison of Efficacy and Safety Between Propranolol and Steroid for Infantile Hemangioma: A Randomized Clinical Trial. JAMA Dermatol. 2017 Jun 1;153(6):529-536. doi: 10.1001/jamadermatol.2017.0250.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Prednisolone	Other / unclassified	2 mg/kg	—
Subject	Propranolol	Small molecule	2 mg/kg	—

Indications