drugset / Trial / NCT01909336
Use of Isotonic Solutions Versus Hypotonic Solutions for Preventing Hospital Acquired Hyponatremia
Phase 3
Completed
161 enrolled
Instituto Tecnologico y de Estudios Superiores de Monterey
Tecnologico de Monterrey · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
The purpose of this study is to determine if isotonic solutions reduce the risk of hospital acquired hyponatremia compared with hypotonic solutions.
Timeline
- Start
- 2013-07
- Primary completion
- 2014-02
- Completion
- 2014-04
Publications
- Background Moritz ML, Ayus JC. Hospital-acquired hyponatremia--why are hypotonic parenteral fluids still being used? Nat Clin Pract Nephrol. 2007 Jul;3(7):374-82. doi: 10.1038/ncpneph0526.
- Background Choong K, Kho ME, Menon K, Bohn D. Hypotonic versus isotonic saline in hospitalised children: a systematic review. Arch Dis Child. 2006 Oct;91(10):828-35. doi: 10.1136/adc.2005.088690. Epub 2006 Jun 5.
- Background Montanana PA, Modesto i Alapont V, Ocon AP, Lopez PO, Lopez Prats JL, Toledo Parreno JD. The use of isotonic fluid as maintenance therapy prevents iatrogenic hyponatremia in pediatrics: a randomized, controlled open study. Pediatr Crit Care Med. 2008 Nov;9(6):589-97. doi: 10.1097/PCC.0b013e31818d3192.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Dextrose | Unknown | 3.3 % | Intravenous |
| Comparator | Dextrose | Unknown | 5 % | Intravenous |
| Comparator | sodium chloride | Unknown | 0.3 % | Intravenous |
| Comparator | sodium chloride | Unknown | 0.45 % | Intravenous |
| Comparator | sodium chloride | Unknown | 0.9 % | Intravenous |
Indications
No indication recorded.