Neoadjuvant Chemotherapy Versus Standard Treatment in Patients With Locally Advanced Colon Cancer

Summary

The purpose of this study is to compare 3 cycles of neoadjuvant (preoperative) chemotherapy + operation with the standard treatment of locally advanced colon cancer, which is operation + 8 cycles of (adjuvant) chemotherapy. Patients receiving neoadjuvant chemotherapy may not need adjuvant chemotherapy after the operation and, if this is the case, they will be spared of 5 cycles of chemotherapy.

Timeline

Start

2013-09

Primary completion

2023-06

Completion

2026-06

Outcome

Missed primary endpoint

paper At 3 years, DFS was 87% in the upfront surgery arm and 83% in the neoadjuvant arm (P = .36). PMID 41779406 ↗

Publications

• Jensen LH, Kjaer M, Diness LV, Hollander NH, Rahr HB, Pfeffer F, Larsen FO, Lindebjerg J, Rafaelsen SR, Hansen TF, Timm S, Loes IM, Gogenur I, Zitnjak D, Andersen F, Petersen LN, Lindskog EB, Poulsen LO, Dahl O. Neoadjuvant Chemotherapy vs Upfront Surgery in Patients With Locally Advanced Colon Cancer: A Randomized Clinical Trial. JAMA Surg. 2026 May 1;161(5):450-458. doi: 10.1001/jamasurg.2026.0085.

Drugs

Indications