Topical and Intravenous Administration of TXA Are Equally Effective in DAA THA

Summary

Through a randomized controlled trial, we will compare the intravenous administration of tranexamic acid with the intra-articular application after a total hip arthroplasty through direct anterior approach. * RCT, prospective study * Academic-monocentric study * Clinical outcome measurements The postoperative blood loss will be the primary outcome. Secondary outcomes are 1. The rate of perioperative and postoperative blood transfusion 2. The number of blood units transfused 3. The length of hospital stay 4. Perioperative given intravenous isotonic fluid The Null-hypothesis is that there is no significant difference in postoperative blood loss between intra-articular and intravenous administration of TXA.

Timeline

Start

2014-07

Primary completion

2015-11

Completion

2015-11

Publications

• Vles GF, Corten K, Driesen R, van Elst C, Ghijselings SG. Hidden blood loss in direct anterior total hip arthroplasty: a prospective, double blind, randomized controlled trial on topical versus intravenous tranexamic acid. Musculoskelet Surg. 2021 Dec;105(3):267-273. doi: 10.1007/s12306-020-00652-0. Epub 2020 Mar 10.

Drugs

Indications