drugset / Trial / NCT01941953
Metformin and 5-fluorouracil for Refractory Colorectal Cancer.
NaSingle-groupOpen-labelTreatment
Summary
This is a phase II trial to evaluate efficacy and safety of Metformin and Fluorouracil in patients with metastatic colorectal cancer (CRC) who have progressed after Oxaliplatin and Irinotecan based chemotherapy.
Timeline
- Start
- 2012-11
- Primary completion
- 2014-11
- Completion
- 2015-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Metformin | Small molecule | 850 mg | Oral |
| Subject | fluorouracil | Small molecule | 425 mg/m2 | — |
| Background | Leucovorin | Small molecule | 50 mg | Intravenous |