drugset / Trial / NCT01943188

Stereotactic Body Radiation Therapy and T-Cell Infusion in Treating Patients With Metastatic Kidney Cancer

NCT01943188

NaSingle-groupOpen-labelTreatment

Summary

This pilot phase I trial studies the side effects and best way to give stereotactic body radiation therapy and T-cell infusion in treating patients with metastatic kidney cancer. Giving total body irradiation before a T-cell infusion stops the growth of cancer cells by stopping them from dividing or killing them. After treatment, stem cells are collected from the patient's blood and stored. Chemotherapy is given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the radiation therapy.

Timeline

Start
2014-05
Primary completion
2016-03
Completion

Drugs

EvaluationDrugModalityDoseRoute
Subject therapeutic autologous lymphocytes Cell therapy Other
Background Cyclophosphamide Other / unclassified Oral