Remifentanil Use in Pediatric Rigid Bronchoscopy
Summary
Purpose: In this study we wanted to compare bolus propofol and ketamine as an adjuvant to remifentanil-based total intravenous anesthesia for pediatric rigid bronchoscopy. Materials and Methods: Forty children under 12 years of age scheduled for rigid bronchoscopy were included. After midazolam premedication, remifentanil infusion 1 µg/kg/min was started and patients were randomly allocated to receive either propofol (Group P) or ketamine (Group K) and mivacurium for muscle relaxation. Anesthesia was maintained with remifentanil infusion 1 µg/kg/min and bolus doses of propofol or ketamine. After rigid bronchoscopy remifentanil 0.05 µg/kg/min was maintained until extubation. Hemodynamic parameters, emergence characteristics and adverse events were evaluated.
Timeline
- Start
- 2005-11
- Primary completion
- 2006-08
- Completion
- 2006-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Ketamine | Small molecule | 0.25 mg/kg | — |
| Comparator | Ketamine | Small molecule | 0.5 mg/kg | — |
| Comparator | Ketamine | Small molecule | 2 mg/kg | — |
| Comparator | Ketamine | Small molecule | 3 mg/kg | — |
| Comparator | Propofol | Small molecule | 0.5 mg/kg | — |
| Comparator | Propofol | Small molecule | 1 mg/kg | — |
| Comparator | Propofol | Small molecule | 2 mg/kg | — |
| Comparator | Propofol | Small molecule | 4 mg/kg | — |
| Comparator | Remifentanil | Small molecule | 0.05 ug/kg | — |
| Comparator | Remifentanil | Small molecule | 1 ug/kg | — |