drugset / Trial / NCT01976065
Regeneration of Pulp-Dentin Development in Teeth With Necrotic Pulps and Immature Roots
Phase 1
Completed
125 enrolled
Kenneth Hargreaves
American Association of Endodontists · collabLoma Linda University · collabUniversity of Maryland, Baltimore · collabUniversity of North Carolina · collab
RandomizedFactorialOpen-labelTreatment
Summary
This multi-center exploratory clinical trial is a randomized trial designed to test whether a regenerative endodontic procedure using tissue engineering principles (REGENDO), or a revascularization (REVASC) endodontic procedure, in comparison to standard apexification treatment using a mineral trioxide aggregate barrier (apexification; APEX), produces a significantly better composite clinical outcome for the treatment of immature permanent teeth with pulpal necrosis.
Timeline
- Start
- 2014-09
- Primary completion
- 2018-09-24
- Completion
- 2018-09-24
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ciprofloxacin | Small molecule | — | — |
| Subject | Metronidazole | Small molecule | — | — |
| Subject | Minocycline | Small molecule | — | — |