drugset / Trial / NCT01976806
The Effects of DHA on Periodontitis
Phase 2
Completed
55 enrolled
Beth Israel Deaconess Medical Center
Harvard Medical School (HMS and HSDM) · collabNational Center for Research Resources (NCRR) · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
The purpose of this study is to determine whether docosahexaenoic acid (DHA) is effective in the treatment of periodontitis in adults.
Timeline
- Start
- 2009-06
- Primary completion
- 2011-09
- Completion
- 2011-09
Outcome
Met primary endpoint
paper DHA supplementation decreased mean pocket depth (-0.29 ± 0.13; p = .03) and gingival index (-0.26 ± 0.13; p = .04). PMID 24970858 ↗
Publications
- Background Naqvi AZ, Mu L, Hasturk H, Van Dyke TE, Mukamal KJ, Goodson JM. Impact of Docosahexaenoic Acid Therapy on Subgingival Plaque Microbiota. J Periodontol. 2017 Sep;88(9):887-895. doi: 10.1902/jop.2017.160398. Epub 2017 May 18.
- Results Naqvi AZ, Hasturk H, Mu L, Phillips RS, Davis RB, Halem S, Campos H, Goodson JM, Van Dyke TE, Mukamal KJ. Docosahexaenoic Acid and Periodontitis in Adults: A Randomized Controlled Trial. J Dent Res. 2014 Aug;93(8):767-73. doi: 10.1177/0022034514541125. Epub 2014 Jun 26.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | DOCONEXENT | Other / unclassified | 2 g | Oral |
| Background | Aspirin | Small molecule | 81 mg | Oral |