drugset / Trial / NCT02019810

Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury

NCT02019810

Phase 2 Unknown 20 enrolled University Hospital, Grenoble
RandomizedCrossoverSingle-blindTreatment

Summary

Severe traumatic brain injury with increased intracranial pressure can lead to decreased cerebral blood flow. Low cerebral blood flow is responsible for secondary lesions, leading to bad prognosis. It is not yet established whether increasing cardiac output in these patients can lead to an increase in cerebral blood flow, although there are some arguments in favor of this hypothesis. The aim of this study is to demonstrate that increasing cardiac output will improve cerebral blood flow in patients with severe traumatic injury and high cerebral pressure.

Timeline

Start
2014-10
Primary completion
2016-06
Completion
2016-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Dobutamine Small molecule
Comparator Norepinephrine Other / unclassified

Indications