Pilot Study Investigating the Feasibility of Determining the Endogenous Glucose Production During a Hypoglycaemia

Summary

Primary objective is to investigate the feasibility and stability of determining the endogenous glucose production during a hypoglycaemic clamp in type 1 diabetes mellitus subjects by a stable tracer to tracee ratio with an enrichment of 4% and a variation below +/-30%. Population: twenty type 1 diabetic subjects Study design: Single-center, open, non- randomized, pilot-study

Timeline

Start

2014-01

Primary completion

2016-03

Completion

2016-03

Publications

• Zenz S, Mader JK, Regittnig W, Brunner M, Korsatko S, Boulgaropoulos B, Magnes C, Raml R, Narath SH, Eller P, Augustin T, Pieber TR. Impact of C-Peptide Status on the Response of Glucagon and Endogenous Glucose Production to Induced Hypoglycemia in T1DM. J Clin Endocrinol Metab. 2018 Apr 1;103(4):1408-1417. doi: 10.1210/jc.2017-01836.

Drugs

Indications