drugset / Trial / NCT02032927

Treatment of Chronic Pain From Osteoarthritis

NCT02032927

RandomizedParallel-groupSingle-blindTreatment

Summary

Osteoarthritis is a common joint disorder in the elder population.The current treatment options include both a non-pharmacological approach (physiokinesitherapy, diet) or if this fails, a pharmacological approach that relies in the first instance on drugs such as paracetamol, non-steroidal anti-inflammatory (including inhibitors of cyclo-oxygenase). However, the use of these drugs is limited, by the roof effect concerning analgesia, and by the potential side effects. When pharmacological treatments with non-opioid medications fail, and a moderate-to-severe pain reduces the quality of life of the patient, international guidelines suggest the use of opioid drugs.

Timeline

Start
2013-06
Primary completion
2015-06
Completion
2015-06

Drugs

EvaluationDrugModalityDoseRoute
Comparator Acetaminophen Small molecule 500 mg Oral
Comparator Codeine Small molecule 30 mg Oral
Comparator Naloxone Small molecule 2.5 mg Oral
Comparator Oxycodone Other / unclassified 5 mg Oral

Indications