drugset / Trial / NCT02032927
Treatment of Chronic Pain From Osteoarthritis
RandomizedParallel-groupSingle-blindTreatment
Summary
Osteoarthritis is a common joint disorder in the elder population.The current treatment options include both a non-pharmacological approach (physiokinesitherapy, diet) or if this fails, a pharmacological approach that relies in the first instance on drugs such as paracetamol, non-steroidal anti-inflammatory (including inhibitors of cyclo-oxygenase). However, the use of these drugs is limited, by the roof effect concerning analgesia, and by the potential side effects. When pharmacological treatments with non-opioid medications fail, and a moderate-to-severe pain reduces the quality of life of the patient, international guidelines suggest the use of opioid drugs.
Timeline
- Start
- 2013-06
- Primary completion
- 2015-06
- Completion
- 2015-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Acetaminophen | Small molecule | 500 mg | Oral |
| Comparator | Codeine | Small molecule | 30 mg | Oral |
| Comparator | Naloxone | Small molecule | 2.5 mg | Oral |
| Comparator | Oxycodone | Other / unclassified | 5 mg | Oral |